Protein Information

Name glutathione reductase
Synonyms GLUR; GR; GRD 1; GRD1; GRase; GSR; Glutathione reductase; GRases…

Compound Information

Name cresol
CAS methylphenol

Reference List

PubMed Abstract RScore(About this table)
1649169 Van Beeumen JJ, Demol H, Samyn B, Bartsch RG, Meyer TE, Dolata MM, Cusanovich MA: Covalent structure of the diheme cytochrome subunit and amino-terminal sequence of the flavoprotein subunit of flavocytochrome c from Chromatium vinosum. J Biol Chem. 1991 Jul 15;266(20):12921-31.


The N terminus of the flavin subunit is homologous to a number of flavoproteins, including succinate dehydrogenase, glutathione reductase, and monamine oxidase.
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11514662 Dym O, Eisenberg D: Sequence-structure analysis of FAD-containing proteins. Protein Sci. 2001 Sep;10(9):1712-28.


Three of these families, exemplified by glutathione reductase (GR), ferredoxin reductase (FR), and p-cresol methylhydroxylase (PCMH) were previously defined, and a family represented by pyruvate oxidase (PO) is newly defined.
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16095622 Koetter JW, Schulz GE: Crystal structure of 6-hydroxy-D-nicotine oxidase from Arthrobacter nicotinovorans. J Mol Biol. 2005 Sep 16;352(2):418-28.


The functionally closely related 6-hydroxy-L-nicotine oxidase processing the L-enantiomer is sequence-related to the greater glutathione reductase family with quite a different chainfold.
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6610071 Roebuck BD, MacMillan DL, Bush DM, Kensler TW: Modulation of azaserine-induced pancreatic foci by phenolic antioxidants in rats. J Natl Cancer Inst. 1984 Jun;72(6):1405-10.


The hepatic activities of glucose-6-phosphate dehydrogenase, glutathione reductase, and glutathione-S-transferases were markedly elevated while catalase and superoxide dismutase activities were unchanged.
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