Protein Information

Name sulfatase
Synonyms ARS; RGS 2; RGS2; RIEG 2; RIEG2; ARS; Arylsulfatase C; nitrocatechol sulfatase…

Compound Information

Name cresol
CAS methylphenol

Reference List

PubMed Abstract RScore(About this table)
2065626 Braunbeck T, Volkl A: Induction of biotransformation in the liver of Eel (Anguilla anguilla L.) by sublethal exposure to dinitro-o-cresol: an ultrastructural and biochemical study. Ecotoxicol Environ Saf. 1991 Apr;21(2):109-27.


Structural changes can be correlated to an increase in hepatic lipid and protein contents as well as stimulation of mitochondrial (cytochrome c oxidase), peroxisomal (catalase, allantoinase, uricase), lysosomal (arylsulfatase), and microsomal (esterase) enzymes.
1(0,0,0,1) Details
9448067 Dills RL, Bellamy GM, Kalman DA: Quantitation of o-, m- and p-cresol and deuterated analogs in human urine by gas chromatography with electron capture detection. J Chromatogr B Biomed Sci Appl. 1997 Dec 5;703(1-2):105-13.

Cresol glucuronides and sulfates in urine were hydrolyzed with beta-glucuronidase and arylsulfatase.
81(1,1,1,1) Details
15177071 Morinaga Y, Fuke C, Arao T, Miyazaki T: Quantitative analysis of cresol and its metabolites in biological materials and distribution in rats after oral administration. Leg Med. 2004 Mar;6(1):32-40.

Endogenous beta-glucuronidase, an enzyme which hydrolyses the glucuronide, existed in rat organs, and it influenced the procedures for cresol hydrolysis of sulfatase.
6(0,0,1,1) Details
15740062 Kilic M, Lindsay RC: Enrichment of cheeses manufactured from cow's and sheep's milk blends with sheep-like species-related alkylphenols. J Agric Food Chem. 2005 Mar 9;53(5):1707-12.


A food-grade arylsulfatase from Aspergillus oryzae (ATCC 20719) was produced using a stimulatory medium, and crude dried cells were used as the enzyme source.
4(0,0,0,4) Details
11301044 Slaus K, Coughtrie MW, Sharp S, Vanhaecke T, Vercruysse A, Rogiers V: Influence of culture system and medium enrichment on sulfotransferase and sulfatase expression in male rat hepatocyte cultures. Biochem Pharmacol. 2001 May 1;61(9):1107-17.

1(0,0,0,1) Details
1445242 Chai CL, Loughlin WA, Lowe G: The stereochemical course of sulphuryl transfer catalysed by arylsulphatase II from Aspergillus oryzae. Biochem J. 1992 Nov 1;287 ( Pt 3):805-12.

2(0,0,0,2) Details
16120820 Martinez AW, Recht NS, Hostetter TH, Meyer TW: Removal of P-cresol sulfate by hemodialysis. J Am Soc Nephrol. 2005 Nov;16(11):3430-6. Epub 2005 Aug 24.


Treatment with sulfatase resulted in recovery of this peak as p-cresol, confirming its identity.
1(0,0,0,1) Details
16441915 Gostner A, Blaut M, Schaffer V, Kozianowski G, Theis S, Klingeberg M, Dombrowski Y, Martin D, Ehrhardt S, Taras D, Schwiertz A, Kleessen B, Luhrs H, Schauber J, Dorbath D, Menzel T, Scheppach W: Effect of isomalt consumption on faecal microflora and colonic metabolism in healthy volunteers. Br J Nutr. 2006 Jan;95(1):40-50.


During the isomalt phase, the activity of bacterial beta-glucosidase decreased (P <0.05) whereas beta-glucuronidase, sulfatase, nitroreductase and urease remained unchanged.
1(0,0,0,1) Details