Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name cresol
CAS methylphenol

Reference List

PubMed Abstract RScore(About this table)
12600960 De Smet R, Van Kaer J, Van Vlem B, De Cubber A, Brunet P, Lameire N, Vanholder R: Toxicity of free p-cresol: a prospective and cross-sectional analysis. Clin Chem. 2003 Mar;49(3):470-8.


In vitro, free p-cresol was higher in a 25 g/L than in a 50 g/L albumin solution (P <0.05).
2(0,0,0,2) Details
1962482 Meier M, Wilke B, Junge W: [Determination of beta-N-acetylglucosaminidase and albumin in urine: comparison of methods and effect of gel filtration in human and rat urine]. Wien Klin Wochenschr Suppl. 1991;189:44-7.

A new kinetic method for determination of beta-N-acetylglucosaminidase (beta-NAG, EC 3.2.1.30) in human and rat urine with chlorophenol red-NAG as substrate is compared to two other methods with 4-nitrophenyl-NAG and 3-cresol-sulfonphthaleinyl-NAG respectively as substrates.
2(0,0,0,2) Details
15213855 Cerini C, Dou L, Anfosso F, Sabatier F, Moal V, Glorieux G, De Smet R, Vanholder R, Dignat-George F, Sampol J, Berland Y, Brunet P: P-cresol, a uremic retention solute, alters the endothelial barrier function in vitro. Thromb Haemost. 2004 Jul;92(1):140-50.


P-cresol was tested at concentrations found in CRF patients, and since p-cresol is protein-bound, experiments were performed with and without physiological concentration of human albumin (4 g/dl).
3(0,0,0,3) Details
19394619 de Loor H, Meijers BK, Meyer TW, Bammens B, Verbeke K, Dehaen W, Evenepoel P: Sodium octanoate to reverse indoxyl sulfate and p-cresyl sulfate albumin binding in uremic and normal serum during sample preparation followed by fluorescence liquid chromatography. J Chromatogr A. 2009 May 29;1216(22):4684-8. Epub 2009 Apr 14.

2(0,0,0,2) Details
457306 Kaziuka EN, Chang TM: In-vitro assessment of the removal of phenols by ACAC hemoperfusion. Int J Artif Organs. 1979 Jul;2(4):215-21.


The in-vitro removal of free phenols by means of perfusion over albumin coated cellulose nitrate microencapsulated activated charcoal (ACAC) was studied.
2(0,0,0,2) Details
812278 Metz A, Schutze A: [A comparative study of total protein and albumin in man, monkey, dog and rat employing different analytical methods (author's transl)]. Z Klin Chem Klin Biochem. 1975 Sep;13(9):423-6.

No such differences occurred with bromo-cresol green, except in rats.
2(0,0,0,2) Details
163640 Hurrell RF, Carpenter KJ: The use of three dye-binding procedures for the assessment of heat damage to food proteins. Br J Nutr. 1975 Jan;33(1):101-15.

For the model materials, binding with cresol red was, in general, higher for heated samples but the results showed no correlation with FDNB-reactive lysine values.
For unheated materials, and for bovine plasma albumin and fat-extracted, dried chicken muscle severely heated in the absence of sugar, Acid Orange 12 binding values (mmol bound dye/kg crude protein (nitrogen times 6-25)) were close to the sum of total histidine, total arginine and reactive lysine contents (mmol/kg crude protein (N times 6-25)), which we have termed HARL values.
1(0,0,0,1) Details
16001213 Gonzalez-Yebra AL, Kornhauser C, Wrobel K, Perez-Luque EL, Wrobel K, Barbosa G: Occupational exposure to toluene and its possible causative role in renal damage development in shoe workers. Int Arch Occup Environ Health. 2006 Mar;79(3):259-64. Epub 2005 Jul 5.


Albumin excretion was similar in the exposed and control groups.
1(0,0,0,1) Details
2295522 Ng TP, Ong SG, Lam WK, Jones MG, Cheung CK, Ong CN: Urinary levels of proteins and metabolites in workers exposed to toluene. Int Arch Occup Environ Health. 1990;62(1):43-6.


We measured urinary excretion of albumin and retinol-binding proteins to investigate the occurrence of early renal dysfunction in 45 paint workers exposed principally to toluene, and in the same number of unexposed control subjects matched individually for sex and age.
1(0,0,0,1) Details
19708977 Jourde-Chiche N, Dou L, Cerini C, Dignat-George F, Vanholder R, Brunet P: Protein-bound toxins--update 2009. Semin Dial. 2009 Jul-Aug;22(4):334-9.


This could be obtained in experiments by setting the dialysate flow rate and the dialyzer mass transfer area coefficient (KoA) at much higher levels than the plasma flow rate, or by adding to the dialysate a sorbent such as activated charcoal or albumin.
1(0,0,0,1) Details
9544614 Miranda MA, Castell JV, Hernandez D, Gomez-Lechon MJ, Bosca F, Morera IM, Sarabia Z: Drug-photosensitized protein modification: identification of the reactive sites and elucidation of the reaction mechanisms with tiaprofenic acid/albumin as model system. Chem Res Toxicol. 1998 Mar;11(3):172-7.

1(0,0,0,1) Details
12616287 : NTP Toxicology and Carcinogenesis Studies of o-Benzyl-p-Chlorophenol (CAS No. 120-32-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Natl Toxicol Program Tech Rep Ser. 1994 Jan;424:1-304.


The albumin/globulin ratios in 120, 240, and 480 mg/kg male rats increased with dose and were the result of net decreases in total globulin.
1(0,0,0,1) Details
6858039 Luk'ianchuk VD: [Molecular mechanisms of interaction between blood serum albumin and dinitroorthocresol]. Vopr Med Khim. 1983 Mar-Apr;29(2):8-11.

Two classes of binding sites were found in the protein molecule: high-affinity site, binding 4 molecules of cresol and a low-affinity site, binding up to 12 molecules.
Binding of dinitroortocresol occurred simultaneously with alteration in the albumin molecule conformation.
1(0,0,0,1) Details
14681860 Brunet P, Dou L, Cerini C, Berland Y: Protein-bound uremic retention solutes. Adv Ren Replace Ther. 2003 Oct;10(4):310-20.


CMPF could alter the metabolism of drugs of inhibiting their binding to albumin and their tubular excretion.
1(0,0,0,1) Details
7171582 Toninello A, Siliprandi N: Restoration of membrane potential in mitochondria deenergized with carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP). Biochim Biophys Acta. 1982 Nov 15;682(2):289-92.


Delta psi abolished by FCCP was also restored, though incompletely, by albumin; a prompt and complete restoration was however achieved upon subsequent addition of dithioerythritol.
1(0,0,0,1) Details
14717914 Dou L, Bertrand E, Cerini C, Faure V, Sampol J, Vanholder R, Berland Y, Brunet P: The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney Int. 2004 Feb;65(2):442-51.


Protein-bound uremic solutes were also tested in the presence of 4% human albumin.
1(0,0,0,1) Details
11499570 Wratten ML, Sereni L, Tetta C: Oxidation of albumin is enhanced in the presence of uremic toxins. Ren Fail. 2001 May-Jul;23(3-4):563-71.

We incubated bovine serum albumin in the presence of carboxymethyllysine (CML) (10 micromol/L (-1) mmol/L), methyl glyoxal (50 micromol/L (-5) mmol/L), p-cresol (100 micromol/L-10 mmol/L) or hippuric acid (200 micromol/L-20 mmol/L) for 16 hours at 37 degrees C and then subsequently added 0.5 mmol/L (-1) mmol of H2O2/HOCl.
4(0,0,0,4) Details