Protein Information

Name prothrombin
Synonyms Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin…

Compound Information

Name griseofulvin
CAS

Reference List

PubMed Abstract RScore(About this table)
3698827 Okino K, Weibert RT: Warfarin-griseofulvin interaction. . Drug Intell Clin Pharm. 1986 Apr;20(4):291-3.

A reduction in the griseofulvin dose resulted in an increase in the prothrombin time and, subsequently, a lowering of the warfarin dose.
38(0,1,2,3) Details
10599028 Matsumura Y, Yokota M, Yoshioka H, Shibata S, Ida S, Takiguchi Y: Acute effects of griseofulvin on the pharmacokinetics and pharmacodynamics of warfarin in rats. J Int Med Res. 1999 Jul-Aug;27(4):167-75.

It has been reported that prothrombin time (PT), which is prolonged by warfarin, is reduced when patients on warfarin also take griseofulvin repeatedly.
43(0,1,3,3) Details