| Name | cytokeratin |
|---|---|
| Synonyms | Cytokeratin; Cytokeratin type II; K6HF; KRT75; keratin 75; Cytokeratin type IIs; keratin 75s |
| Name | griseofulvin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1380022 | Cadrin M, Marceau N, French SW: Cytokeratin of apparent high molecular weight in livers from griseofulvin-fed mice. Lab Invest. 1993 Jan;68(1):71-81. |
12(0,0,2,2) | Details |
| 18603402 | Robin MA, Descatoire V, Pessayre D, Berson A: Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Hepatology. 1990 Apr;11(4):652-61. The formation of MDB has been previously reproduced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine or griseofulvin administration which cross-link CK8 by tissue transglutaminase, thus forming an entangled network, from which MDB progressively arise. |
2(0,0,0,2) | Details |
| 1720496 | Preisegger KH, Zatloukal K, Spurej G, Denk H: Changes of cytokeratin filament organization in human and murine Mallory body-containing livers as revealed by a panel of monoclonal antibodies. Liver. 1991 Aug;11(4):231-40. Mallory bodies (MBs) are characteristics morphologic features of alcoholic hepatitis and can be produced in mouse hepatocytes by chronic griseofulvin (GF) intoxication. |
2(0,0,0,2) | Details |
| 2445643 | Katsuma Y, Swierenga SH, Khettry U, Marceau N, French SW: Changes in the cytokeratin intermediate filament cytoskeleton associated with Mallory body formation in mouse and human liver. Liver. 1991 Oct;11(5):300-9. Frozen sections of griseofulvin-fed mouse liver and human liver of primary biliary cirrhosis and primary sclerosing cholangitis were extracted by Triton X-100 and nuclease. |
2(0,0,0,2) | Details |
| 7678660 | Kachi K, Cadrin M, French SW: Synthesis of Mallory body, intermediate filament, and microfilament proteins in liver cell primary cultures. Lab Invest. 1989 Dec;61(6):609-22. RESULTS: Autoradiography of polyacrylamide gel electrophoresis showed [35S] was incorporated into three major bands: cytokeratin 55, cytokeratin 49, and actin in control and GF hepatocytes. EXPERIMENTAL DESIGN: Primary cultures of hepatocytes isolated from griseofulvin (GF)-fed mice and control mice were used. |
2(0,0,0,2) | Details |
| 6169613 | Denk H, Franke WW, Dragosics B, Zeiler I: Pathology of cytoskeleton of liver cells: demonstration of mallory bodies (alcoholic hyalin) in murine and human hepatocytes by immunofluorescence microscopy using antibodies to cytokeratin polypeptides from hepatocytes. Lab Invest. 1988 Dec;59(6):848-56. |
1(0,0,0,1) | Details |
| 2135694 | Leevy CB, Sameshima Y, Yoshioka K, Leevy CM, Kanagasundaram N, Unoura M: Use of a specific monoclonal antibody to detect Mallory bodies in liver disease. J Assoc Acad Minor Phys. 1990;1(2):24-5 Immunofluorescence studies with anti-NMB-1, a Mallory body-specific monoclonal antibody, indicate that this is a sensitive method for recognizing Mallory bodies in cryostat sections of liver from griseofulvin-treated mice or patients with liver disease. The NMB-1 epitope which facilitates morphologic and clinical detection of Mallory bodies is distinct from cytokeratin and appears to be responsible for its immunogenicity. |
1(0,0,0,1) | Details |
| 1691733 | Zatloukal K, Spurej G, Rainer I, Lackinger E, Denk H: Fate of Mallory body-containing hepatocytes: disappearance of Mallory bodies and restoration of the hepatocytic intermediate filament cytoskeleton after drug withdrawal in the griseofulvin-treated mouse. Lab Invest. 1984 Mar;50(3):303-12. The appearance of Mallory bodies in hepatocytes is associated with derangement of the cytokeratin intermediate filament cytoskeleton, at least as revealed by immunofluorescence and suggested by immunoelectron microscopy. |
1(0,0,0,1) | Details |
| 1705301 | Zatloukal K, Bock G, Rainer I, Denk H, Weber K: High molecular weight components are main constituents of Mallory bodies isolated with a fluorescence activated cell sorter. Hepatology. 1981 Jan-Feb;1(1):9-20. Mallory bodies (MBs) are cytoplasmic filamentous aggregates containing cytokeratin (CK) material. They occur in hepatocytes of patients with alcoholic liver disease (i.e., alcoholic hepatitis) and can also be induced experimentally in mice by chronic griseofulvin intoxication. |
1(0,0,0,1) | Details |
| 16729998 | Roomi MW, Gaal K, Yuan QX, French BA, Fu P, Bardag-Gorce F, French SW: Preneoplastic liver cell foci expansion induced by thioacetamide toxicity in drug-primed mice. Hepatology. 1987 Nov-Dec;7(6):1215-23. Mice primed by feeding griseofulvin or diethyl 1,4-dihydro 1,4,6-trimethyl 3,5- decarboxylate for 5 months followed by drug withdrawal for 1 month (drug-primed mice) were given thioacetamide intraperitoneally, and the livers were subsequently studied at intervals up to 7 days. Mallory bodies were identified by immunoperoxidase stains for ubiquitin and cytokeratin. |
1(0,0,0,1) | Details |
| 6192789 | French SW: Present understanding of the development of Mallory's body. Toxicol In Vitro. 2008 Sep;22(6):1511-9. Epub 2008 Jul 7. Mallory's body filament assembly includes polypeptides of the cytokeratin class of intermediate filaments and also higher molecular weight polypeptides normally found only in the cytokeratins of mature keratinocytes of the epidermis. |
1(0,0,0,1) | Details |
| 8137902 | Kachi K, Wong PT, French SW: Molecular structural changes in Mallory body proteins in human and mouse livers: an infrared spectroscopy study. J Hepatol. 1992 Mar;14(2-3):226-31. To study the molecular structure of Mallory body (MB) proteins we applied infrared spectroscopy of the isolated MBs from livers obtained from autopsied patients with alcoholic cirrhosis and griseofulvin-fed (GF-fed) mice. The relative amount of beta-sheets was increased compared to the alpha-helices in the MBs, indicating that conformational changes in the cytokeratin peptides of the MBs had occurred. |
1(0,0,0,1) | Details |
| 6199585 | Irie T, Benson NC, French SW: Electron microscopic study of the in vitro -dependent degradation of Mallory bodies and intermediate filaments in hepatocytes. Exp Mol Pathol. 2006 Aug;81(1):8-14. Epub 2006 May 24. Isolated crude fractions of intermediate filaments (IFs) from livers of control and griseofulvin-fed mice were incubated with (Ca2+) or ethylene glycol bis (beta-aminoethyl ether)-N,N'-tetraacetic acid (EGTA). |
0(0,0,0,0) | Details |
| 1658525 | Woltsche M, Zatloukal K, Denk H: Enzyme-histochemical studies of griseofulvin-intoxicated mouse livers. Exp Mol Pathol. 1993 Dec;59(3):197-210. |
0(0,0,0,0) | Details |
| 1692099 | Zatloukal K, Denk H, Spurej G, Lackinger E, Preisegger KH, Franke WW: High molecular weight component of Mallory bodies detected by a monoclonal antibody. Exp Cell Res. 1985 Nov;161(1):161-71. To identify Mallory body (MB) constituents, monoclonal antibodies to murine MBs induced by long-term griseofulvin (GF) feeding were produced. |
0(0,0,0,0) | Details |
| 2481150 | Kawahara H, Marceau N, French SW: Excretory function in cultured hepatocytes from griseofulvin-treated mice. Lab Invest. 1990 Apr;62(4):427-34. We determined the role of cytokeratin (CK) intermediate filaments in the excretory function of hepatocytes in cultured hepatocytes containing Mallory bodies (MBs) from the livers of griseofulvin (GF)-fed mice. |
31(0,1,1,1) | Details |
| 2462130 | Ohta M, Marceau N, Perry G, Manetto V, Gambetti P, Autilio-Gambetti L, Metuzals J, Kawahara H, Cadrin M, French SW: Ubiquitin is present on the cytokeratin intermediate filaments and Mallory bodies of hepatocytes. Arch Pathol Lab Med. 1983 Sep;107(9):445-50. To investigate the relationship of cytokeratin intermediate filaments (IFs) and Mallory bodies (MBs) to the regulatory protein ubiquitin, the griseofulvin-fed mouse was examined by double-label immunocytochemistry. |
16(0,0,2,6) | Details |
| 2414118 | Denk H, Lackinger E, Cowin P, Franke WW: Maintenance of desmosomes in mouse hepatocytes after drug-induced rearrangement of cytokeratin filament material. Lab Invest. 1986 May;54(5):543-53. The distribution of desmosomes and cytokeratin filaments (tonofilaments) in hepatocytes of normal mice and those intoxicated with griseofulvin was studied by immunofluorescence microscopy. |
13(0,0,2,3) | Details |
| 7536860 | Cadrin M, Anderson NM, Aasheim LH, Kawahara H, Franks DJ, French SW: Modifications in cytokeratin and actin in cultured liver cells derived from griseofulvin-fed mice. Lab Invest. 1991 Feb;64(2):200-6. |
7(0,0,1,2) | Details |
| 6184592 | Denk H, Krepler R, Lackinger E, Artlieb U, Franke WW: Immunological and biochemical characterization of the keratin-related component of Mallory bodies: a pathological pattern of hepatocytic cytokeratins. 28-30. Mallory bodies induced by long-term griseofulvin feeding in mouse liver were isolated and analyzed by one- and two-dimensional gel electrophoresis and reaction of the separated polypeptides with cytokeratin antibodies using the blotting technique. |
7(0,0,1,2) | Details |
| 2422438 | Hazan R, Denk H, Franke WW, Lackinger E, Schiller DL: Change of cytokeratin organization during development of Mallory bodies as revealed by a monoclonal antibody. Hepatology. 1996 Sep;24(3):603-12. A monoclonal murine antibody (KM 54-5) was produced against Mallory body (MB) material isolated from liver tissue of griseofulvin treated mice. |
5(0,0,0,5) | Details |
| 8781332 | Yuan QX, Marceau N, French BA, Fu P, French SW: Mallory body induction in drug-primed mouse liver. . Liver. 1982 Sep;2(3):165-75. A model was developed where MB formation was induced by refeeding either of the drugs griseofulvin or diethyl 1,4-dihydro-1,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC). Western blots showed a progressive increase in the cytokeratin proteins (CK49 and CK55) and actin while refeeding the drugs. |
2(0,0,0,2) | Details |