Protein Information

Name CD4
Synonyms CD4; CD4 antigen (p55); CD4 molecule; CD4mut; T cell antigen T4/LEU3; T cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; T cell surface glycoprotein CD4 precursor…

Compound Information

Name streptomycin
CAS

Reference List

PubMed Abstract RScore(About this table)
19920896 Nikolaeva LG, Maystat TV, Masyuk LA, Pylypchuk VS, Volyanskii YL, Kutsyna GA: Changes in CD4+ T-cells and HIV RNA resulting from combination of anti-TB therapy with Dzherelo in TB/HIV dually infected patients. Drug Des Devel Ther. 2009 Feb 6;2:87-93.

The arm A (n = 20) received isoniazid (H); rimfapicin (R); pyrazinamide (Z); streptomycin (S); and ethambutol (E), and arm B (n = 20) received 50 drops of Dzherelo twice per day in addition to HRZSE.
4(0,0,0,4) Details
18442788 Nikolaeva LG, Maystat TV, Pylypchuk VS, Volyanskii YL, Masyuk LA, Kutsyna GA: Effect of oral immunomodulator Dzherelo in TB/HIV co-infected patients receiving anti-tuberculosis therapy under DOTS. Int Immunopharmacol. 2008 Jun;8(6):845-51. Epub 2008 Feb 29.

The arm A, which served as a control, received Isoniazid (H); Rimfapicin (R); Pyrazinamide (Z); Streptomycin (S); and Ethambutol (E), and arm B received 50 drops of Dzherelo twice per day in addition to the daily dose of HRZSE.
The population of CD4 T-cells expanded in Dzherelo arm (174 to 283; P=0.00003) but declined in ATT group (182 to 174; P=0.34).
2(0,0,0,2) Details
18697487 Ogawa E, Murata M, Ohnishi H, Tatsukawa M, Sawayama Y, Furusyo N, Hayashi J: [AIDS-related Mycobacterium avium infection dissemination in a patient with endobronchial lesions associated with immune reconstitution inflammatory syndrome]. Kansenshogaku Zasshi. 2008 Jul;82(4):341-6.


In August 2004, a 26-year-old Japanese woman with fever and general lymphadenopathy was diagnosed with AIDS (HIV-1 RNA 5.7 x 10 (5) copies/mL, CD4+ T cell count 10/microL) and disseminated Mycobacterium avium (M. avium) infection, for which antimycobacterial treatment was initiated.
2(0,0,0,2) Details
15875919 Nunes EA, De Capitani EM, Coelho E, Joaquim OA, Figueiredo IR, Cossa AM, Panunto AC, Carvalho-Ramos M: Patterns of anti-tuberculosis drug resistance among HIV-infected patients in Maputo, Mozambique, 2002-2003. Int J Tuberc Lung Dis. 2005 May;9(5):494-500.

Cultures of 111 patients were tested for rifampicin, isoniazid, streptomycin and ethambutol sensitivity.
Chest X-ray, haemoglobin (Hb), total lymphocyte and CD4 counts were also performed.
2(0,0,0,2) Details
19009216 Nunes EA, De Capitani EM, Coelho E, Panunto AC, Joaquim OA, Ramos Mde C: Mycobacterium tuberculosis and nontuberculous mycobacterial isolates among patients with recent HIV infection in Mozambique. J Bras Pneumol. 2008 Oct;34(10):822-8.


The median CD4 lymphocyte count in this group was 134 cells/mm (3).
1(0,0,0,1) Details
18826574 Ngowi BJ, Mfinanga SG, Bruun JN, Morkve O: Pulmonary tuberculosis among people living with HIV/AIDS attending care and treatment in rural northern Tanzania. BMC Public Health. 2008 Sep 30;8:341.

Nineteen isolates (95%) were susceptible to rifampicin, isoniazid, streptomycin and ethambutol (the first line tuberculosis drugs).
Blood samples were collected for CD4+ T cells count.
1(0,0,0,1) Details
17352100 Sungkanuparph S, Eampokalap B, Chottanapund S, Thongyen S, Manosuthi W: Impact of drug-resistant tuberculosis on the survival of HIV-infected patients. Int J Tuberc Lung Dis. 2007 Mar;11(3):325-30.

The median CD4 cell count at TB diagnosis was 44 cells/mm3.
Sixty-three (28%) patients were infected with Mycobacterium tuberculosis resistant to at least one drug; respectively 16.4%, 9.3%, 5.3% and 12.9% were resistant to isoniazid (INH), rifampicin (RMP), ethambutol and streptomycin, and 14 (6.2%) had multidrug-resistant TB (MDR-TB).
1(0,0,0,1) Details
18710511 Urassa W, Mugusi F, Villamor E, Msamanga G, Moshiro C, Bosch R, Saathoff E, Fawzi W: Primary antimicrobial resistance among Mycobacterium tuberculosis isolates from HIV seropositive and HIV seronegative patients in Dar es Salaam Tanzania. BMC Res Notes. 2008 Jul 31;1:58.

Antimicrobial susceptibility testing was done on four antimicrobial agents namely streptomycin, isoniazid, ethambutol and rifampicin.
HIV testing and CD4+ T lymphocytes enumeration were also done.
1(0,0,0,1) Details
19052412 Chandra Gupta TS, Rayudu T, Murthy SV: Donovanosis with auto-amputation of penis in a HIV-2 infected person. Indian J Dermatol Venereol Leprol. 2008 Sep-Oct;74(5):490-2.


The old conventional medicines, viz. streptomycin, doxycycline and amoxycillin, were effective.
0(0,0,0,0) Details