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Pommier Y, Marchand C: Interfacial inhibitors of protein-nucleic acid interactions. . Curr Med Chem Anticancer Agents. 2005 Jul;5(4):421-9.
We will also provide examples generalizing the interfacial inhibitor concept to inhibitors of topoisomerase II (anthracyclines, ellipticines, epipodophyllotoxins), gyrase (quinolones, ciprofloxacin, norfloxacin), RNA polymerases (alpha-amanitin and actinomycin D), and ribosomes (antibiotics such as streptomycin, hygromycin B, tetracycline, kirromycin, fusidic acid, thiostrepton, and possibly cycloheximide). |
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