Protein Information

Name immunoglobulins (protein family or complex)
Synonyms Immunoglobulin; Immunoglobulins

Compound Information

Name thiomersal
CAS

Reference List

PubMed Abstract RScore(About this table)
466248 Haeney MR, Carter GF, Yeoman WB, Thompson RA: Long-term parenteral exposure to mercury in patients with hypogammaglobulinaemia. Br Med J. 1979 Jul 7;2(6181):12-4.

Patients with hypogammaglobulinaemia commonly receive regular long-term replacement therapy with a concentrate of pooled normal human immunoglobulin G (IgG) containing an organic mercury compound (thiomersal) as a preservative.
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11672919 Marth E, Kleinhappl B: Albumin is a necessary stabilizer of TBE-vaccine to avoid fever in children after vaccination. Vaccine. 2001 Nov 12;20(3-4):532-7.

Albumin or immunoglobulin prevents a rise of cytokines so that it is recommended to add the albumin again to the vaccine.
A thiomersal-free and also an albumin-free tick-borne encephalitis-vaccine (TBE-vaccine) was developed.
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18680530 Ponyai G, Hidvegi B, Nemeth I, Sas A, Temesvari E, Karpati S: Contact and aeroallergens in adulthood atopic dermatitis. . J Eur Acad Dermatol Venereol. 2008 Nov;22(11):1346-55. Epub 2008 Aug 1.

In the IG, a late thiomersal positivity was detected without clinical relevance.
Furthermore, we examined the relevance of APT, specific immunoglobulin E (IgE) tests and Prick tests.
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9441496 Semotan K, Kalab D: [A new method of preparation of bovine colostral immunoglobulins for parenteral administration in calves]. Vet Med. 1997 Sep;42(9):249-52.

For parenteral application in calves the above solution of immunoglobulins was subsequently adjusted to 9-11% content of protein, 0.9% of sodium chloride, pH 7.2, stabilized with 2% of aminoacetic acid and conserved with 0.015% of thiomersal.
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11368282 van't Veen AJ: Vaccines without thiomersal: why so necessary, why so long coming? . Drugs. 2001;61(5):565-72.

Both the potential toxicity of thiomersal and sensitisation to thiomersal in relation to the application of thiomersal-containing vaccines and immunoglobulins, especially in children, have been debated in the literature.
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