Protein Information

Name isocitrate dehydrogenase
Synonyms ICD M; IDH; IDP; NADP(+) specific ICDH; Oxalosuccinate decarboxylase; IDH 2; IDH2; IDHM…

Compound Information

Name lindane
CAS (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
12959551 De Coen WM, Janssen CR: A multivariate biomarker-based model predicting population-level responses of Daphnia magna. Environ Toxicol Chem. 2003 Sep;22(9):2195-201.

The results of the short-term exposure (48 h-96 h) to eight model toxicants (cadmium, chromium, mercury, tributyl tin, linear alkylsulfonic acid, sodium pentachlorophenolate, lindane, and 2,4-dichlorophenoxyacetic acid) on the following biomarkers were used for the multivariate model: digestive enzymes (amylase, cellulase, beta-galactosidase, trypsin, and esterase), enzymes of the intermediary metabolism (glycogen phosphorylase, glucose-6-phosphate dehydrogenase, pyruvate kinase, lactate dehydrogenase, and isocitrate dehydrogenase), cellular energy allocation (CEA) (protein, carbohydrate, and lipid content and electron transport activity), and DNA damage and antioxidative stress activity.
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1723596 Philip GH, Reddy PM, Ramamurthi R: Changes in the carbohydrate metabolism in the selected tissues of Mus booduga gray after BHC treatment. Biochem Int. 1991 Aug;24(6):1165-71.


Enzymes of TCA cycle namely isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH) were inhibited suggesting abnormality in mitochondrial oxidative metabolism as a consequence of BHC toxicity.
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18951770 Bhatt DK, Bano M: Modulation of tricarboxylic acid cycle dehydrogenases during hepatocarcinogenesis induced by hexachlorocyclohexane in mice. Exp Toxicol Pathol. 2009 Jul;61(4):325-32. Epub 2008 Oct 31.


The activity of TCA cycle enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), and malate dehydrogenase (MDH) have been studied.
1(0,0,0,1) Details