| Name | sterol 14 alpha demethylase |
|---|---|
| Synonyms | CP51; CYPL 1; CYPL1; CYP51; CYP51A1; CYPLI; Cytochrome P450 51A1; LDM… |
| Name | triadimenol |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2205265 | Yoshida Y, Aoyama Y: Stereoselective interaction of an azole antifungal agent with its target, lanosterol 14 alpha-demethylase (cytochrome P-45014DM): a model study with stereoisomers of triadimenol and purified cytochrome P-45014DM from yeast. Chirality. 1990;2(1):10-5. The effect of the four triadimenol stereoisomers on the purified yeast lanosterol 14 alpha-demethylase (cytochrome P-45014DM), the primary target of azole antifungal agents, was studied. (1S,2R)-Triadimenol was the most potent demethylase inhibitor and bound quantitatively to the enzyme below 0.05 microM. |
112(1,2,2,2) | Details |
| 9868783 | Lamb DC, Kelly DE, Manning NJ, Hollomon DW, Kelly SL: Expression, purification, reconstitution and inhibition of Ustilago maydis sterol 14 alpha-demethylase (CYP51; P450 (14DM)). FEMS Microbiol Lett. 1998 Dec 15;169(2):369-73. Triadimenol and tebuconazole are potent inhibitors of the sterol 14 alpha-demethylation reaction in fungi which is catalysed by CYP51, a haem-thiolate containing enzyme belonging to the cytochrome P450 monooxygenase superfamily. |
90(1,1,2,5) | Details |
| 11396979 | Lamb DC, Cannieux M, Warrilow AG, Bak S, Kahn RA, Manning NJ, Kelly DE, Kelly SL: Plant sterol 14 alpha-demethylase affinity for azole fungicides. Biochem Biophys Res Commun. 2001 Jun 15;284(3):845-9. Using purified CYP51 from the plant Sorghum bicolor L Moenech, a direct comparison of the sensitivity to the fungicides triadimenol and tebuconazole has been carried out. |
10(0,0,1,5) | Details |
| 15916909 | Wyand RA, Brown JK: Sequence variation in the CYP51 gene of Blumeria graminis associated with resistance to sterol demethylase inhibiting fungicides. Fungal Genet Biol. 2005 Aug;42(8):726-35. However, genetic analysis of resistance to the DMI triadimenol indicates that mutation of the CYP51 gene is not the only mechanism of resistance operating in B. graminis. |
5(0,0,0,5) | Details |