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Villeneuve DL, Blake LS, Brodin JD, Greene KJ, Knoebl I, Miracle AL, Martinovic D, Ankley GT: Transcription of key genes regulating gonadal steroidogenesis in control and ketoconazole- or vinclozolin-exposed fathead minnows. Toxicol Sci. 2007 Aug;98(2):395-407. Epub 2007 May 21.
Exposure to VZ, an antiandrogen expected to indirectly impact steroidogenesis, increased pituitary expression of follicle-stimulating hormone beta-subunit as well as testis expression of 20beta-hydroxysteroid dehydrogenase and luteinizing hormone receptor transcripts. |
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