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Cowin PA, Foster P, Pedersen J, Hedwards S, McPherson SJ, Risbridger GP: Early-onset endocrine disruptor-induced prostatitis in the rat. Environ Health Perspect. 2008 Jul;116(7):923-9.
OBJECTIVES: In this study we aimed to evaluate effects of in utero exposure to the antiandrogenic EDC vinclozolin, during the period of male reproductive tract development, on neonatal, prepubertal, and postpubertal prostate gland function of male offspring.
Prostatic inflammation was associated with phosphorylation and nuclear translocation of nuclear factor-kappa B (NFkappaB) and postpubertal activation of proinflammatory NFkappaB-dependent genes, including the chemokine interleukin-8 and the cytokine transforming growth factor-beta1. |
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