Protein Information

Name GRP78
Synonyms 78 kDa glucose regulated protein; MIF 2; MIF2; 78 kDa glucose regulated protein precursor; BIP; Endoplasmic reticulum lumenal Ca(2+) binding protein grp78; GRP 78; GRP78…

Compound Information

Name vinclozolin
CAS 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione

Reference List

PubMed Abstract RScore(About this table)
20189627 Lemos MF, Esteves AC, Samyn B, Timperman I, van Beeumen J, Correia A, van Gestel CA, Soares AM: Protein differential expression induced by endocrine disrupting compounds in a terrestrial isopod. Chemosphere. 2010 Apr;79(5):570-6. Epub 2010 Mar 1.

We have used a dose/response approach to unravel the protein expression in different organs of isopods exposed to bisphenol A (BPA) and vinclozolin (Vz) and assess their potential use as surrogate species.
EDCs affected proteins involved in the energy metabolism (arginine kinase), proteins of the heat shock protein family (Hsp70 and GRP78) and most likely microtubule dynamics (tubulin).
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15686871 Rosen MB, Wilson VS, Schmid JE, Gray LE: Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone. Reprod Toxicol. 2005 Jan-Feb;19(3):367-79.

Three of the down-regulated genes, GRP78 (BiP), Dad1, and mitochondrial aspartate aminotransferase have been previously shown to be directly androgen regulated.
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