Protein Information

Name P60
Synonyms ARHGEF 5; p60; TIM1; TIM; ARHGEF5; GEF 5; GEF5; Guanine nucleotide regulatory protein TIM…

Compound Information

Name vinclozolin
CAS 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione

Reference List

PubMed Abstract RScore(About this table)
15279874 Uzumcu M, Suzuki H, Skinner MK: Effect of the anti-androgenic endocrine disruptor vinclozolin on embryonic testis cord formation and postnatal testis development and function. Reprod Toxicol. 2004 Aug-Sep;18(6):765-74.

The adult P60 sperm motility was significantly lower in vinclozolin exposed males (P < 0.01).
13(0,0,2,3) Details
16837734 Anway MD, Memon MA, Uzumcu M, Skinner MK: Transgenerational effect of the endocrine disruptor vinclozolin on male spermatogenesis. J Androl. 2006 Nov-Dec;27(6):868-79. Epub 2006 Jul 12.

Although the P60 testis morphology was predominantly normal, the germ cell apoptosis was significantly increased in the testes cross sections of animals from the vinclozolin generations.
6(0,0,1,1) Details