Protein Information

Name Dnmt3A
Synonyms DNA (cytosine 5) methyltransferase 3A; DNA (cytosine 5-) methyltransferase 3 alpha; DNA MTase Hsa3A; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3 alpha isoform a variant; DNA cytosine methyltransferase 3A2; DNA methyltransferase 3A; DNA methyltransferase Hsa3A…

Compound Information

Name vinclozolin
CAS 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione

Reference List

PubMed Abstract RScore(About this table)
18042343 Anway MD, Rekow SS, Skinner MK: Transgenerational epigenetic programming of the embryonic testis transcriptome. Genomics. 2008 Jan;91(1):30-40. Epub 2007 Nov 26.

Embryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination appears to promote an epigenetic reprogramming of the male germ line that is associated with transgenerational adult-onset disease states.
The most dramatic effects were on the germ-line-associated Dnmt3A and Dnmt3L isoforms.		 1(0,0,0,1) Details