Protein Information

Name CD1
Synonyms CD1; CD1A; CD1C; CD1c antigen; CD1c molecule; R7; T cell surface glycoprotein CD1c; T cell surface glycoprotein CD1c precursor…

Compound Information

Name vinclozolin
CAS 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione

Reference List

PubMed Abstract RScore(About this table)
18940246 Elzeinova F, Novakova V, Buckiova D, Kubatova A, Peknicova J: Effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice. Reprod Toxicol. 2008 Nov-Dec;26(3-4):231-8. Epub 2008 Oct 5.
12(0,0,2,2) Details
8921505 Hrelia P, Fimognari C, Maffei F, Vigagni F, Mesirca R, Pozzetti L, Paolini M, Cantelli Forti G: The genetic and non-genetic toxicity of the fungicide Vinclozolin. . Mutagenesis. 1996 Sep;11(5):445-53.

Several cytochrome P450 (CYP)-dependent reactions have been monitored in liver, kidney and lung microsomes of male and female Swiss Albino CD1 mice in order to ascertain certain toxic non-genetic properties (related to carcinogenesis) of Vinclozolin.
6(0,0,1,1) Details
17686559 Canistro D, Pozzetti L, Sapone A, Broccoli M, Affatato AA, Stradiotti A, Longo V, Menichini P, Barale R, Paolini M: Perturbation of murine liver cyp-superfamily of isoforms by different combinations of pesticide mixtures. Food Chem Toxicol. 2008 Jan;46(1):34-42. Epub 2007 Jun 28.

It was previously found that fenarimol, vinclozolin or acephate, three of the most used pesticides worldwide, provoked a marked perturbation of murine cytochrome P450 (CYP)-linked monooxygenases.
Here, to more closely mimic human exposure, it was investigated whether different pesticide combinations administered i.p. in male Swiss Albino CD1 mice in single or repeated fashion (daily, for three consecutive days), affect CYP-dependent oxidations.
1(0,0,0,1) Details