| 12788061 |
Watanabe H, Adachi R, Hirayama A, Kasahara T, Suzuki K: Triphenyltin enhances the neutrophilic differentiation of promyelocytic HL-60 cells. Biochem Biophys Res Commun. 2003 Jun 20;306(1):26-31.
To assess the effect of TPT on leukocyte differentiation, we investigated its effect on the neutrophilic differentiation of HL-60 cells induced by dimethyl sulfoxide and granulocyte colony-stimulating factor (G-CSF) for 6 days.
Real-time PCR analysis revealed that TPT augmented the expression not only of CD18 but also of components of superoxide-generating NADPH-oxidase, p47phox, 2.7-fold, and p67phox, 2.0-fold, and of granulocyte colony-stimulating factor receptor (G-CSFR), 3.0-fold, whereas various other endocrine disruptors, including parathion, vinclozolin, and bisphenol A, had no such enhancing effects. |
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