Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name captan
CAS

Reference List

PubMed Abstract RScore(About this table)
8509224 Hasegawa R, Cabral R, Hoshiya T, Hakoi K, Ogiso T, Boonyaphiphat P, Shirai T, Ito N: Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats. Int J Cancer. 1993 May 28;54(3):489-93.

The number of glutathione S-transferase placental-form-positive liver-cell foci was significantly increased in the captan- and phosmet-treated groups.
6(0,0,1,1) Details
1862543 Cabral R, Hoshiya T, Hakoi K, Hasegawa R, Fukushima S, Ito N: A rapid in vivo bioassay for the carcinogenicity of pesticides. Tumori. 1991 Jun 30;77(3):185-8.

Hepatocarcinogenic potential was assessed by comparing the number and area of glutathione s-transferase (placental form) -positive foci in the liver with those of controls given diethylnitrosamine alone.
Positive results were seen with Chinomethionat, Phosmet and Propiconazole; the results obtained with Captan and Prochloraz were borderline; Benomyl, Daminozide and Folpet gave negative results.
1(0,0,0,1) Details
9022123 Kim HC, Cha SW, Song SW, Ha CS, Han SS, Roh JK, Lee YS, Furukawa F, Nishikawa A, Takahashi M: Enhancing effects of captafol on the development of GST-P-positive liver cell foci in a medium-term bioassay, and protection by L-cysteine of the enhancement in rats. Cancer Lett. 1997 Jan 1;111(1-2):15-20.


The modifying effects of captafol and protective effects of L-cysteine on the development of glutathione S-transferase placental form-positive (GST-P +) foci of the liver and expression of proliferating cell nuclear antigen (PCNA) in the kidney were investigated in a medium-term bioassay using D-galactosamine (DGA) in rats.
1(0,0,0,1) Details
7683635 Tsuda H, Matsumoto K, Ogino H, Ito M, Hirono I, Nagao M, Sato K, Cabral R, Bartsch H: Demonstration of initiation potential of carcinogens by induction of preneoplastic glutathione S-transferase P-form-positive liver cell foci: possible in vivo assay system for environmental carcinogens. Jpn J Cancer Res. 1993 Mar;84(3):230-6.


Initiating potential was assayed on the basis of significant increase in values of preneoplastic placental form glutathione S-transferase-positive (GST-P+) foci of more than 3 cells in cross section at week 10.
1(0,0,0,1) Details
12941561 Choi JW, Kim YK, Song SY, Lee IH, Lee WH: Optical biosensor consisting of glutathione-S-transferase for detection of captan. Biosens Bioelectron. 2003 Oct 15;18(12):1461-6.
12(0,0,2,2) Details