Protein Information

Name zonula occludens 1
Synonyms TJP 1; TJP1; Tight junction protein 1; Tight junction protein 1 isoform a; Tight junction protein ZO 1; ZO 1; ZO1; Zona occludens 1…

Compound Information

Name lindane
CAS (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
11532877 Defamie N, Mograbi B, Roger C, Cronier L, Malassine A, Brucker-Davis F, Fenichel P, Segretain D, Pointis G: Disruption of gap junctional intercellular communication by lindane is associated with aberrant localization of connexin43 and zonula occludens-1 in 42GPA9 Sertoli cells. Carcinogenesis. 2001 Sep;22(9):1537-42.

These results suggest that lindane inhibits GJIC between Sertoli cells and that aberrant Cx43/ZO-1 localization may be responsible for this effect.
37(0,1,2,2) Details
19033388 Gilleron J, Fiorini C, Carette D, Avondet C, Falk MM, Segretain D, Pointis G: Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen. J Cell Sci. 2008 Dec 15;121(Pt 24):4069-78. Epub 2008 Nov 25.

6(0,0,0,6) Details
15194225 Segretain D, Fiorini C, Decrouy X, Defamie N, Prat JR, Pointis G: A proposed role for ZO-1 in targeting connexin 43 gap junctions to the endocytic pathway. Biochimie. 2004 Apr-May;86(4-5):241-4.

5(0,0,0,5) Details