Protein Information

Name CDR1
Synonyms CDR; CDR; CDR 1; CDR1; CDR34; CDR62A; Cerebellar degeneration related antigen 1; Cerebellar degeneration related autoantigen 1…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
10052898 Maesaki S, Marichal P, Hossain MA, Sanglard D, Vanden Bossche H, Kohno S: Synergic effects of tactolimus and azole antifungal agents against azole-resistant Candida albican strains. J Antimicrob Chemother. 1998 Dec;42(6):747-53.

The CDR1-expressing resistant strain C26 accumulated less itraconazole than the CaMDR-expressing resistant strain C40 or the azole-sensitive strain B2630.
The addition of sodium azide, an electron-transport chain inhibitor, increased the intracellular accumulation of itraconazole only in the C26 strain, and not in the C40 or B2630 strains.
3(0,0,0,3) Details
11766100 Yang HC, Mikami Y, Imai T, Taguchi H, Nishimura K, Miyaji M, Branchini ML: Extrusion of fluorescein diacetate by multidrug-resistant Candida albicans. Mycoses. 2001 Nov;44(9-10):368-74.

There was no significant difference in the accumulation of calcein AM between MDR cells and drug-susceptible cells of C. albicans even with sodium azide, suggesting that calcein AM may not be associated with the CDR1-gene-related multidrug efflux system of C. albicans.
However, a structurally related prefluorochrome derivative, fluorescein diacetate (FDA), was shown to be extruded by the CDR1 mRNA-overexpressing yeast cells.
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