| Name | cytochrome c |
|---|---|
| Synonyms | CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16951741 | Kambayashi Y, Hitomi Y, Kodama N, Kubo M, Okuda J, Takemoto K, Shibamori M, Takigawa T, Ogino K: pH profile of cytochrome c-catalyzed nitration. Acta Biochim Pol. 2006;53(3):577-84. Epub 2006 Sep 4. The cytochromec-catalyzed nitration of was inhibited by catalase, sodium azide, and |
7(0,0,0,7) | Details |
| 16540393 | Chen Q, Lesnefsky EJ: Depletion of and cytochrome c during ischemia increases peroxide production from the electron transport chain. Free Radic Biol Med. 2006 Mar 15;40(6):976-82. Epub 2005 Nov 8. |
5(0,0,0,5) | Details |
| 11500038 | Das N, Gupta S, Mazumdar S: Direct observation of release of cytochrome c from lipid-encapsulated protein by peroxide and a possible mechanism for drug-induced apoptosis. Biochem Biophys Res Commun. 2001 Aug 17;286(2):311-4. The protein encapsulated inside vesicles did not form complex with sodium azide solution added externally. |
5(0,0,0,5) | Details |
| 10707086 | Goldstein JC, Waterhouse NJ, Juin P, Evan GI, Green DR: The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nat Cell Biol. 2000 Mar;2(3):156-62. |
5(0,0,0,5) | Details |
| 7622786 | Goyal N, Srivastava VM: Oxidation and reduction of cytochrome c by mitochondrial enzymes of Setaria cervi. J Helminthol. 1995 Mar;69(1):13-7. Sodium azide activated the reductases but substantially inhibited the oxidase activity. |
3(0,0,0,3) | Details |
| 14709344 | Grammatopoulos TN, Morris K, Bachar C, Moore S, Andres R, Weyhenmeyer JA: Angiotensin II attenuates chemical hypoxia-induced caspase-3 activation in primary cortical neuronal cultures. Brain Res Bull. 2004 Jan 15;62(4):297-303. In this study we determined whether caspase-3 is required in mouse cortical neurons for sodium azide-mediated apoptosis. Levels of cytochrome-c release and caspase-3 cleavage were assayed by Western analysis. |
2(0,0,0,2) | Details |
| 17056004 | Mubarakshina M, Khorobrykh S, Ivanov B: reduction in chloroplast thylakoids results in production of peroxide inside the membrane. Biochim Biophys Acta. 2006 Nov;1757(11):1496-503. Epub 2006 Sep 20. peroxide production in isolated pea thylakoids was studied in the presence of cytochrome c to prevent disproportionation of radicals outside of the thylakoid membranes. Neither the presence of a superoxide dismutase inhibitor, or sodium azide, in the thylakoid suspension, nor unstacking of the thylakoids appreciably affected the partitioning of electrons to peroxide production. |
2(0,0,0,2) | Details |
| 10597238 | Suzuki S, Higuchi M, Proske RJ, Oridate N, Hong WK, Lotan R: Implication of mitochondria-derived reactive species, cytochrome C and caspase-3 in N-(4-hydroxyphenyl) retinamide-induced apoptosis in cervical carcinoma cells. Oncogene. 1999 Nov 4;18(46):6380-7. |
2(0,0,0,2) | Details |
| 19349686 | Brooks C, Wei Q, Cho SG, Dong Z: Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest. 2009 May;119(5):1275-85. doi: 10.1172/JCI37829. Epub 2009 Apr 6. Following either ATP depletion or cisplatin treatment of rat renal tubular cells, mitochondrial fragmentation was observed prior to cytochrome c release and apoptosis. |
1(0,0,0,1) | Details |
| 15500948 | Ding X, Xu Q, Liu F, Zhou P, Gu Y, Zeng J, An J, Dai W, Li X: monomethyl ether photodynamic damage on HeLa cells by means of reactive species production and cytosolic free concentration elevation. Cancer Lett. 2004 Dec 8;216(1):43-54. Sodium azide (the singlet quencher) or (the scavenger) could protect HeLa cells from the apoptosis and necrosis induced by HMME-PDT, showing that reactive species (ROS), such as singlet and played a decisive role in HMME-PDT-induced HeLa cells death. Cytochrome C (Cyto C) release from mitochondria into cytosol and Caspase-3 activation after HMME-PDT were inhibited by BAPTA/AM (an intracellular chelator). |
1(0,0,0,1) | Details |
| 11193033 | Benitez-Bribiesca L, Gomez-Camarillo M, Castellanos-Juarez E, Mravko E, Sanchez-Suarez P: Morphologic, biochemical and molecular mitochondrial changes during reperfusion phase following brief renal ischemia. Ann N Y Acad Sci. 2000;926:165-79. Ischemia/reperfusion of organs and cells induces apoptosis through a complicated series of changes in mitochondria, mainly the generation of free radicals, permeability transitions, translocations, and release of apoptogenic factors such as cytochrome c and Bcl-2 family members. A model of chemical hypoxia with intra-arterial 50 mM sodium azide served as comparison, allowing free blood flow for 30, 60, 120 and 180 min. |
1(0,0,0,1) | Details |
| 20036216 | Hur J, Lee P, Kim MJ, Kim Y, Cho YW: Ischemia-activated microglia induces neuronal injury via activation of gp91phox oxidase. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1526-30. Epub 2009 Dec 28. MCM-treated SH-SY5Y cells showed reduced the viability, increased caspase-3 activity, decreased Bcl-2/Bax ratio, and increased cytochrome c release, increased inflammatory cytokines, and increased reactive species (ROS) generation. |
1(0,0,0,1) | Details |
| 20203294 | Ranzato E, Biffo S, Burlando B: Selective Toxicity to Malignant Mesothelioma: A Redox Trojan Mechanism. Am J Respir Cell Mol Biol. 2010 Mar 4. transport inhibitors sodium azide and ouabain did not reduce toxicity . Mesothelioma cells showed much higher production (revealed by cytochrome c reduction assay) and NOX4 expression (revealed by Western blot) than mesothelial cells. |
1(0,0,0,1) | Details |
| 12590362 | Ho KJ, Liu TK, Huang TS, Lu FJ: Humic acid mediates iron release from ferritin and promotes lipid peroxidation in vitro: a possible mechanism for humic acid-induced cytotoxicity. Arch Toxicol. 2003 Feb;77(2):100-9. Epub 2002 Dec 17. In addition, the increase in HA-induced lipid peroxidation is partially inhibited by sodium azide (a singlet scavenger) or disodium 4,5-dihydroxy-1,3--disulfonic acid (a scavenger), reflecting the involvement of singlet and in the process of lipid peroxidation. The addition of HA into a reaction system has been shown to generate in a dose-dependent manner by the superoxide dismutase-inhibitable cytochrome c reduction assay. |
1(0,0,0,1) | Details |
| 10408245 | Kunimoto S, Nosaka C, Takeuchi T: Stimulation of cellular XTT reduction by cytochrome oxidase inhibitors. . Biol Pharm Bull. 1999 Jun;22(6):660-1. It is suggested that XTT reduction is coupled with the respiratory chain via cytochrome c, which is located between complexes III and IV (cytochrome oxidase). |
1(0,0,0,1) | Details |
| 15004018 | Wang J, Wei Q, Wang CY, Hill WD, Hess DC, Dong Z: Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem. 2004 May 7;279(19):19948-54. Epub 2004 Mar 5. The protection occurred at mitochondria, involving the suppression of Bax accumulation, outer membrane damage, and cytochrome c release. |
1(0,0,0,1) | Details |
| 9509413 | An SS, Kim YM: Purification and characterization of a manganese-containing superoxide dismutase from a carboxydobacterium, Pseudomonas carboxydohydrogena. Mol Cells. 1997 Dec 31;7(6):730-7. Sodium azide, but not and peroxide, was found to inhibit the enzyme activity. The final specific activity was 2,396 units per mg protein as determined by an assay based on a 50% decrease in the rate of cytochrome c reduction. |
1(0,0,0,1) | Details |
| 8628756 | Linetsky M, Ortwerth BJ: Quantitation of the reactive species generated by the UVA irradiation of -glycated lens proteins. Photochem Photobiol. 1996 May;63(5):649-55. High concentrations of sodium azide, a known singlet quencher, inhibited the photolytic destruction of both His and Trp. attained a level of 76 microM as determined by the superoxide dismutase (SOD)-dependent increase in peroxide formation and of 52 microM by the SOD-inhibitable reduction of cytochrome c. |
1(0,0,0,1) | Details |
| 17646712 | Seo SN, Lee JH, Kim YM: Characterization of an iron- and manganese-containing superoxide dismutase from Methylobacillus sp. strain SK1 DSM 8269. Mol Cells. 2007 Jun 30;23(3):370-8. peroxide and sodium azide, but not was found to inhibit the purified enzyme. The final specific activity was 4,831 units per milligram protein as determined by an assay based on a 50% decrease in the rate of cytochrome c reduction. |
1(0,0,0,1) | Details |
| 17045927 | Lu Z, Tao Y, Zhou Z, Zhang J, Li C, Ou L, Zhao B: Mitochondrial reactive species and -mediated cancer cell apoptosis in 2-butylamino-2-demethoxyhypocrellin B photodynamic treatment. Free Radic Biol Med. 2006 Nov 15;41(10):1590-605. Epub 2006 Aug 30. It was found that exposure of the cells to 2-BA-2-DMHB and irradiation resulted in a significant increase of intracellular ROS in minutes, and then followed by cytoplasmic free enhancement, mitochondrial synthase (mtNOS) activation, cytochrome c release, and apoptotic death. |
1(0,0,0,1) | Details |
| 15659779 | Chun YS, Yeo EJ, Suh HJ, Park JW: Spontaneous generation of reactive species in the mixture of and Ann N Y Acad Sci. 2004 Dec;1030:43-51. However, and sodium azide in combination do not produce such artifacts and thus may be used as an alternative. In this study, we demonstrate that a mixture of and reduced cytochrome c and nitroblue tetrazolium, both of which are indicators. |
1(0,0,0,1) | Details |
| 8531024 | Tesfa-Selase F, Hay RJ: Superoxide dismutase of Cryptococcus neoformans: purification and characterization. J Med Vet Mycol. 1995 Jul-Aug;33(4):253-9. Superoxide dismutase activity was also assayed using cytochrome c. The enzyme was inhibited by sodium azide, o-phenanthroline, and EDTA, in descending order. |
1(0,0,0,1) | Details |
| 15519459 | Verdin A, Lounes-Hadj Sahraoui A, Newsam R, Robinson G, Durand R: Polycyclic aromatic hydrocarbons storage by Fusarium solani in intracellular lipid vesicles. Environ Pollut. 2005 Jan;133(2):283-91. Sodium azide, a cytochrome c oxidation inhibitor, and the two cytoskeleton inhibitors colchicine and cytochalasin did not prevent the transport and accumulation of PAH in lipid vesicles of F. solani hyphae. |
0(0,0,0,0) | Details |
| 8747893 | Salman-Tabcheh S, Guerin MC, Torreilles J: Potential role of the peroxidase-dependent metabolism of in lowering the polymorphonuclear leukocyte bactericidal function. Free Radic Res. 1996 Jan;24(1):61-8. The addition of catalase or sodium azide substantially reduced this binding. |
0(0,0,0,0) | Details |