Protein Information

Name muscles
Synonyms COX 7a M; COX VIIa M; COX7A; COX7A1; COX7A1 protein; COX7AH; COX7AM; Cytochrome c oxidase subunit 7a H…

Compound Information

Name lindane
CAS (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
11461840 van Wyk E, Bouwman H, van der Bank H, Verdoorn GH, Hofmann D: Persistent organochlorine pesticides detected in blood and tissue samples of vultures from different localities in South Africa. Comp Biochem Physiol C Toxicol Pharmacol. 2001 Jul;129(3):243-64.

Statistically significant (P <0.05) differences between populations were detected in geometric means calculated for gamma-BHC (lindane), alpha (cis)-chlordane and alpha-endosulfan.
Five of the organochlorine contaminants displayed significant variations between concentrations detected in the clotted blood, organs and muscles excised from vulture carcasses.
1(0,0,0,1) Details
18963306 Tao S, Liu WX, Li XQ, Zhou DX, Li X, Yang YF, Yue DP, Coveney RM: Organochlorine pesticide residuals in chickens and eggs at a poultry farm in Beijing, China. Environ Pollut. 2009 Feb;157(2):497-502. Epub 2008 Oct 28.


Mean fresh weight concentrations of HCHs and DDTs were 0.122+/-0.061 ng/g and 0.051+/-0.038 ng/g in the muscles.
1(0,0,0,1) Details
16094878 Takazawa Y, Kitamura K, Yoshikane M, Shibata Y, Morita M, Tanaka A: Distribution patterns of hexachlorocyclohexanes and other organochlorine compounds in muscles of fish from a Japanese remote lake during 2002-2003. Bull Environ Contam Toxicol. 2005 Apr;74(4):652-9.

1(0,0,0,1) Details
17420036 Zhou R, Zhu L, Kong Q: Persistent chlorinated pesticides in fish species from Qiantang River in East China. Chemosphere. 2007 Jun;68(5):838-47. Epub 2007 Apr 8.

Total concentrations of OCPs in fish muscles ranged from 7.43 to 143.79 ng g (-1) wet weight (ww) with highest concentration recorded in sole fish (Cynoglossus abbreviatus), a benthic carnivore.
Among the OCPs analyzed, DDE, gamma-HCH and heptachlor were the predominant contaminants in fish muscle, which indicated that there was recent input of lindane.
1(0,0,0,1) Details
12533964 Kiziewicz B, Czeczuga B: Accumulation and loss of Lindane in the muscles, liver and brain of some freshwater fish after intoxication with gamacarbatox suspension. Rocz Akad Med Bialymst. 2002;47:226-34.
18(0,0,3,3) Details
18281745 Sauviat MP, Pages N: Effects of lindane (gamma-hexachlorocyclohexane) on rat heart muscle contraction. Gen Physiol Biophys. 2007 Dec;26(4):275-80.

The effects of micromolar concentrations of lindane on the mechanical activity of cardiac left ventricular papillary muscles were studied in adult female rats.
6(0,0,1,1) Details
16839592 Kunisue T, Takayanagi N, Tsubota T, Tanabe S: Persistent organochlorines in raccoon dogs (Nyctereutes procyonoides) from Japan: Hepatic sequestration of oxychlordane. Chemosphere. 2007 Jan;66(2):203-11. Epub 2006 Jul 12.


In livers of RDs, CHLs were remarkably dominant (20 times higher than PCBs) followed by PCBs> DDTs> HCHs> HCB, whereas the chemicals in muscles were in the order of CHLs> PCBs> HCHs> DDTs> HCB.
3(0,0,0,3) Details
19344928 Waszak I, Dabrowska H: Persistent organic pollutants in two fish species of Percidae and sediment from the Sulejowski Reservoir in central Poland. Chemosphere. 2009 May;75(9):1135-43. Epub 2009 Apr 2.


Polychlorinated biphenyls (PCBs), hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), heptachlor, and DDTs were measured in the fish muscles.
3(0,0,0,3) Details
15914239 Sapozhnikova Y, Zubcov N, Hungerford S, Roy LA, Boicenco N, Zubcov E, Schlenk D: Evaluation of pesticides and metals in fish of the Dniester River, Moldova. Chemosphere. 2005 Jul;60(2):196-205.

Maximum total DDT pesticide concentrations were between 27.7 and 34.2 ng/g wet weight in muscles and gonads, respectively.
Chlordane and lindane were also detected in amounts up to 37 and 76 ng/g wet weight in gonads, respectively.
3(0,0,0,3) Details
15870838 Sauviat MP, Bouvet S, Godeau G, Pages N: Electrical activity alterations induced by chronic absorption of lindane (gamma-hexachlorocyclohexane) trace concentrations in adult rat heart. Can J Physiol Pharmacol. 2005 Mar;83(3):243-51.

The left ventricle (LV) presents a hypertrophied area, atrophied papillary muscles, and unorganized collagen bundles and layers.
2(0,0,0,2) Details
16538862 Benjamin N, Kushwah A, Sharma RK, Katiyar AK: Histopathological changes in liver, kidney and muscles of pesticides exposed malnourished and diabetic rats. Indian J Exp Biol. 2006 Mar;44(3):228-32.

2(0,0,0,2) Details
15041284 Sapozhnikova Y, Bawardi O, Schlenk D: Pesticides and PCBs in sediments and fish from the Salton Sea, California, USA. Chemosphere. 2004 May;55(6):797-809.

DDE concentrations in fish muscles tissues were above the 50 ng/g concentration threshold for the protection of predatory birds.
Lindane, dieldrin, dichlorodiphenylethane (DDE) and total PCB concentrations detected in sediments exceeded probable effect levels established for freshwater ecosystems, and pp-DDE and total PCB concentrations were higher than effect range-median values developed for marine and estuarine sediments.
1(0,0,0,1) Details