| Name | HPRT |
|---|---|
| Synonyms | HGPRT; hPrt1; HGPRTase; HPRT; HPRT 1; HPRT1 protein; Hypoxanthine phosphoribosyltransferase 1; Hypoxanthine guanine phosphoribosyltransferase… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8293552 | Koch WH, Henrikson EN, Kupchella E, Cebula TA: Salmonella typhimurium strain TA100 differentiates several classes of carcinogens and mutagens by base substitution specificity. Carcinogenesis. 1994 Jan;15(1):79-88. HPRT, aprt, supF) revealed a high concordance between these targets. The mutational specificity of N-methylnitrosourea (MNU), nitrosoguanidine (MNNG), methyl methanesulfonate (MMS), sodium azide (NaN3), 4-nitroquinoline oxide (4NQO), benzo [a] pyrene (BP), nitrofurantoin (NF), adriamycin (ADM) and UVA-activated in Salmonella typhimurium strain TA100 has been examined using allele-specific oligonucleotide hybridization and DNA sequence analyses. |
1(0,0,0,1) | Details |
| 10567037 | Giri AK, Mukhopadhyay A, Sun J, Hsie AW, Ray S: Antimutagenic effects of centchroman--a contraceptive and a candidate drug for breast cancer in multiple mutational assays. Mutagenesis. 1999 Nov;14(6):613-20. The potent anti-oestrogenic activity, negligible side-effects and anti-breast cancer activity of CC prompted us to evaluate the antimutagenic effects of this compound in a bacterial mutagenicity assay and CHO/HPRT and AS52/GPT mutation assays in vitro and in vivo in female Swiss albino mice as measured by both sister chromatid exchange (SCE) and chromosome aberrations (CA) against three known positive mutagen compounds, dimethylbenz [a] anthracene (DMBA), cyclophosphamide (CP) and mitomycin C (MMC). Antimutagenicity assays in Salmonella strains TA97a, TA100, TA98 and TA102 were carried out against commonly used known positive mutagens, sodium azide, 4-nitro-o-phenylenediamine, cumine hydroperoxide, 2-aminofluorene and danthron. |
3(0,0,0,3) | Details |
| 9506887 | Li J, Ayyadevera R, Shmookler Reis RJ: Carcinogens stimulate intrachromosomal homologous recombination at an endogenous locus in human diploid fibroblasts. Mutat Res. 1997 Dec;385(3):173-93. These cells are therefore sensitive to selection in HAT medium, against cells lacking functional HPRT enzyme. In contrast, 5 non-carcinogenic agents, including two 'Ames-positive' chemicals, sodium azide and 8-hydroxyquinoline, evoked no more than a 1.7-fold increase in reversion (not significant). |
2(0,0,0,2) | Details |