| Name | phospholipase C |
|---|---|
| Synonyms | PLC L; PLCE; PLC L (PLC epsilon); PLCL; PLCL 1; PLCL1; PLDL 1; PLDL1… |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11097267 | Lu CH, Lee KC, Chen YC, Cheng JS, Yu MS, Chen WC, Jan CR: Lindane (gamma-hexachlorocyclohexane) induces internal Ca2+ release and capacitative Ca2+ entry in Madin-Darby canine kidney cells. Pharmacol Toxicol. 2000 Oct;87(4):149-55. |
0(0,0,0,0) | Details |
| 11798014 | Wang CT, Peters-Golden M, Loch-Caruso R: A -independent phospholipase activity insensitive to bromoenol lactone mediates release by lindane in rat myometrial cells. Life Sci. 2001 Dec 14;70(4):453-70. |
0(0,0,0,0) | Details |
| 7536436 | Senar S, Puente JC, Lopez-Aparicio P, Recio MN, Perez-Albarsanz MA: Increased intracellular glycerophosphoinositol and are biochemical markers for lindane toxicity. Cell Signal. 1994 Nov;6(8):915-21. |
0(0,0,0,0) | Details |
| 12140177 | Wang CT, Loch-Caruso R: Phospholipase-mediated inhibition of spontaneous oscillatory uterine contractions by lindane in vitro. Toxicol Appl Pharmacol. 2002 Jul 15;182(2):136-47. These data suggest that lindane inhibits myometrial gap junctions and spontaneous oscillatory contractions by a phospholipase C-mediated pathway. |
143(1,3,3,3) | Details |
| 12645305 | Sauviat MP, Pages N: [Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane] . J Soc Biol. 2002;196(4):339-48. Lindane produces a Ca2+ influx in mice peritoneal macrophage cells responsible for the Ca2+ induced Ca2+ release produced by phospholipase C via IP3 pathway and resulting in a maintained increase of the free cytosolic Ca2+ concentration. |
81(1,1,1,1) | Details |
| 7510960 | Pinelli E, Cambon C, Tronchere H, Chap H, Teissie J, Pipy B: Ca (2+)-dependent activation of phospholipases C and D from mouse peritoneal macrophages by a selective trigger of Ca2+ influx, gamma-hexachlorocyclohexane. Biochem Biophys Res Commun. 1994 Mar 15;199(2):699-705. This was responsible for Ca (2+)-induced Ca2+ release via produced by phospholipase C and resulted in a sustained increase of cytoplasmic free Ca2+ concentration ([Ca2+] i). |
2(0,0,0,2) | Details |
| 11833466 | Pinelli E, Pipy B, Teissie J, Gabriel B: oscillations induced by lindane in peritoneal macrophages of mice: control by the maturation stage of the macrophage]. J Soc Biol. 2001;195(3):285-95. The maintainance of these oscillations depended on mobilization from intracellular stores by InsP3, since neomycin and 8-(diethylamino) octyl 3,4,5-trimethoxybenzoate (TMB-8) abolished the oscillations. gamma-HCCH induced a transient entry which triggered phospholipase C activation and the associated [Ca2+] i oscillations. |
1(0,0,0,1) | Details |