Protein Information

Name Glut 4
Synonyms GLUT 4; GLUT4; Glucose transporter 4; SLC2A4; Solute carrier family 2 member 4; Glucose transporter 4s; Solute carrier family 2 member 4s

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
18067996 Guan F, Yu B, Qi GX, Hu J, Zeng DY, Luo J: Chemical hypoxia-induced glucose transporter-4 translocation in neonatal rat cardiomyocytes. Arch Med Res. 2008 Jan;39(1):52-60. Epub 2007 Oct 15.

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9685425 Hresko RC, Heimberg H, Chi MM, Mueckler M: Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP. J Biol Chem. 1998 Aug 7;273(32):20658-68.


Subcellular fractionation experiments demonstrated that reduction in insulin-stimulated 2-deoxyglucose uptake by glucosamine was due to an inhibition of translocation of both Glut 1 and Glut 4 from the low density microsomes (LDM) to the plasma membrane.
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17957036 Brown AE, Elstner M, Yeaman SJ, Turnbull DM, Walker M: Does impaired mitochondrial function affect insulin signaling and action in cultured human skeletal muscle cells?. Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E97-102. Epub 2007 Oct 23.

GLUT1 mRNA expression remained unchanged, whereas GLUT4 mRNA expression increased following azide treatment.
To address this, a model of impaired cellular respiratory function was established by incubating human skeletal muscle cell cultures with the mitochondrial inhibitor sodium azide and examining the effects on insulin action.
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