Protein Information

Name signal peptidase (protein family or complex)
Synonyms Signal peptidase; Signal peptidase complex; Signal peptidases

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
11470353 Nguyen DT, Houssin C, Bayan N: Study of mycoloyl transferase transport across the cell envelope of Corynebacterium glutamicum. FEMS Microbiol Lett. 2001 Jul 24;201(2):145-50.

The transport of PS1 to the cell wall is slow and occurs through two energetically distinct steps: the first one, which includes processing by signal peptidase, is rapid and inhibited by sodium azide or carbonyl cyanide m-chlorophenylhydrazone.
81(1,1,1,1) Details
9871019 Cavard D: Inhibition of colicin synthesis by the antibiotic globomycin. Arch Microbiol. 1998 Dec;171(1):50-8.

The antibiotic globomycin, an inhibitor of LspA (the lipoprotein signal peptidase), inhibited synthesis of colicin by Escherichia coli cells grown in rich medium.
The Gbc phenotype was affected by growth conditions since it was partially or totally suppressed in cells subjected to high temperatures, treated with sodium azide, or grown in minimal medium.
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10518748 Morosoli R, Dupont C: Secretion of xylanase A2 in Streptomyces lividans: dependence on signal peptides length, number and composition. FEMS Microbiol Lett. 1999 Oct 15;179(2):437-45.


Furthermore, S. lividans rapidly degraded XlnA2 either when deprived of its sp or in the absence of the signal peptidase cleavage site.
1(0,0,0,1) Details