Protein Information

Name AMPK
Synonyms 5' AMP activated protein kinase subunit beta 1; AMPK; 5' AMP activated protein kinase beta 1 subunit; AMP activated protein kinase beta subunit; AMP activated protein kinase beta 1 non catalytic subunit; AMPK beta 1 chain; AMPK beta1; AMPKb…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
12730239 Wang W, Yang X, Lopez de Silanes I, Carling D, Gorospe M: Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. J Biol Chem. 2003 Jul 18;278(29):27016-23. Epub 2003 May 1.

In the present investigation, treatment of human fibroblasts with AMPK activators such as 5-amino-imidazole-4-carboxamide riboside, antimycin A, and sodium azide inhibited cell growth and lowered the expression of proliferative genes.
38(0,1,1,8) Details
16943243 Jing M, Ismail-Beigi F: Critical role of 5'-AMP-activated protein kinase in the stimulation of glucose transport in response to inhibition of oxidative phosphorylation. Am J Physiol Cell Physiol. 2007 Jan;292(1):C477-87. Epub 2006 Aug 30.

Here we found that treatment of Glut1-expressing Clone 9 cells with sodium azide (5 mM for 2 h) or the AMPK activator 5'-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR, 2 mM for 2 h) stimulated the rate of glucose transport by two- to fourfold.
36(0,1,1,6) Details
19840997 Kreneisz O, Benoit JP, Bayliss DA, Mulkey DK: AMP-activated protein kinase inhibits TREK channels. J Physiol. 2009 Dec 15;587(Pt 24):5819-30. Epub .

AMP-activated protein kinase (AMPK) is a serine/threonine kinase activated by conditions that increase the AMP : ATP ratio.
Metabolic inhibition by sodium azide can also inhibit both TREK and TASK channels.
7(0,0,0,7) Details
18067996 Guan F, Yu B, Qi GX, Hu J, Zeng DY, Luo J: Chemical hypoxia-induced glucose transporter-4 translocation in neonatal rat cardiomyocytes. Arch Med Res. 2008 Jan;39(1):52-60. Epub 2007 Oct 15.


BACKGROUND: AMP-activated protein kinase (AMPK) activation plays an essential role in glucose metabolism of the heart.
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18563357 Han M, Im DS: Effects of mitochondrial inhibitors on cell viability in U937 monocytes under glucose deprivation. Arch Pharm Res. 2008 Jun;31(6):749-57. Epub 2008 Jun 19.

In glucose deprivation condition, intracellular ATP content is decreased and thereby AMP-activated protein kinase (AMPK) is activated.
Mitochondrial inhibitors such as rotenone, TTFA, antimycin A, sodium azide, oligomycin, and valinomycin were used in this study.
1(0,0,0,1) Details