| Name | aminophospholipid translocase |
|---|---|
| Synonyms | ATP8A1; ATPASEII; ATPIA; ATPP 2; ATPP2; ATPase II; ATPase class I type 8A member 1; Aminophospholipid translocase… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11584374 | Ujhazy P, Ortiz D, Misra S, Li S, Moseley J, Jones H, Arias IM: Familial intrahepatic cholestasis 1: studies of localization and function. . Hepatology. 2001 Oct;34(4 Pt 1):768-75. This report describes the localization of Fic1 in rat liver and intestine, as well as biochemical and transfection studies that support its function as an energy-dependent aminophospholipid translocase. In canalicular membrane vesicles, translocase activity had an initial velocity of 3.3 nmol (PS) translocated per milligram of protein per minute and a K (m) (ATP) = 1.2 mmol/L; was inhibited by vanadate, N-ethylmaleimide, sodium azide, and and was unidirectional (i.e., from the outer to the inner canalicular plasma membrane leaflet). |
1(0,0,0,1) | Details |
| 8375469 | Julien M, Tournier JF, Tocanne JF: Differences in the transbilayer and lateral motions of fluorescent analogs of and phosphatidylethanolamine in the apical plasma membrane of bovine aortic endothelial cells. Exp Cell Res. 1993 Oct;208(2):387-97. This "flip" process, which occurred at 20 degrees C, was abolished when the endothelial cells were preincubated with N-ethylmaleimide, diamide, vanadate (VO4 (3-)) and vanadyl (VO2+) ions, a set of substances which inhibit aminophospholipid translocase activity in various systems, and with a combination of sodium azide and 2-deoxyglucose which led to nearly complete ATP depletion in the cells. |
32(0,1,1,2) | Details |