Protein Information

Name c reactive protein
Synonyms C reactive protein; PTX 1; PTX1; C reactive protein precursor; CRP; C reactive protein precursors

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
15725942 Lafuente N, Azcutia V, Matesanz N, Cercas E, Rodriguez-Manas L, Sanchez-Ferrer CF, Peiro C: Evidence for sodium azide as an artifact mediating the modulation of inducible nitric oxide synthase by C-reactive protein. J Cardiovasc Pharmacol. 2005 Mar;45(3):193-6.
82(1,1,1,2) Details
19415183 Wang HH, Yeh HI, Wang CY, Su CH, Wu YJ, Tseng YY, Lin YC, Tsai CH: C-reactive protein, sodium azide, and endothelial connexin43 gap junctions. Cell Biol Toxicol. 2010 Apr;26(2):153-63. Epub 2009 May 5.
12(0,0,2,2) Details
15319265 van den Berg CW, Taylor KE, Lang D: C-reactive protein-induced in vitro vasorelaxation is an artefact caused by the presence of sodium azide in commercial preparations. Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):e168-71. Epub 2004 Aug 19.
7(0,0,1,2) Details
15976313 Liu C, Wang S, Deb A, Nath KA, Katusic ZS, McConnell JP, Caplice NM: Proapoptotic, antimigratory, antiproliferative, and antiangiogenic effects of commercial C-reactive protein on various human endothelial cell types in vitro: implications of contaminating presence of sodium azide in commercial preparation. Circ Res. 2005 Jul 22;97(2):135-43. Epub 2005 Jun 23.
7(0,0,1,2) Details
9471299 Stajner A: [Use of sodium azide for precipitation of C-reactive protein with rivanol] Epidemiol Mikrobiol Imunol. 1997 Sep;46(3):128.
6(0,0,1,1) Details
16847147 Zhong Y, Li SH, Liu SM, Szmitko PE, He XQ, Fedak PW, Verma S: C-Reactive protein upregulates receptor for advanced glycation end products expression in human endothelial cells. Hypertension. 2006 Sep;48(3):504-11. Epub 2006 Jul 17.

Human saphenous vein endothelial cells were incubated with human recombinant CRP, free of sodium azide and endotoxin.
2(0,0,0,2) Details
17531242 Nabata A, Kuroki M, Ueba H, Hashimoto S, Umemoto T, Wada H, Yasu T, Saito M, Momomura S, Kawakami M: C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: Implications for the destabilization of atherosclerotic plaque. Atherosclerosis. 2008 Jan;196(1):129-35. Epub 2007 May 24.

However, recent in vitro studies raised the possibility that the effects of CRP are caused by biologically active contaminants such as sodium azide and endotoxin.
2(0,0,0,2) Details
18293141 Singh SK, Suresh MV, Voleti B, Agrawal A: The connection between C-reactive protein and atherosclerosis. . Ann Med. 2008;40(2):110-20.

Many of these responses indicate proatherogenic functions of CRP but are being reinvestigated using CRP preparations that are free of endotoxins, sodium azide, and biologically active peptides derived from the protein itself.
2(0,0,0,2) Details
19191104 Kikuchi K, Kohyama T, Yamauchi Y, Kato J, Takami K, Okazaki H, Desaki M, Nagase T, Rennard SI, Takizawa H: C-reactive protein modulates human lung fibroblast migration. Exp Lung Res. 2009 Feb;35(1):48-58.

2(0,0,0,2) Details
15563529 Swafford AN Jr, Bratz IN, Knudson JD, Rogers PA, Timmerman JM, Tune JD, Dick GM: C-reactive protein does not relax vascular smooth muscle: effects mediated by sodium azide in commercially available preparations. Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1786-95. Epub 2004 Nov 24.

C-reactive protein (CRP), an acute-phase protein and newly recognized indicator of cardiovascular risk, may have direct actions on the vascular wall.
1(0,0,0,1) Details
16636017 Oroszlan M, Herczenik E, Rugonfalvi-Kiss S, Roos A, Nauta AJ, Daha MR, Gombos I, Karadi I, Romics L, Prohaszka Z, Fust G, Cervenak L: Proinflammatory changes in human umbilical cord vein endothelial cells can be induced neither by native nor by modified CRP. Int Immunol. 2006 Jun;18(6):871-8. Epub 2006 Apr 24.

The role of C-reactive protein (CRP) in atherosclerosis is controversial.
CRP preparations were carefully analyzed by biochemical, immunological and cell biological methods in order to avoid endotoxin or sodium azide contamination as well as inappropriate conformational changes, which together had possibly been the main reason for the previously published controversial results.
1(0,0,0,1) Details
16723683 Doronzo G, Russo I, Trovati M, Anfossi G: Sodium azide in commercially available C-reactive protein preparations does not influence matrix metalloproteinase-2 synthesis and release in cultured human aortic vascular smooth muscle cells. Clin Chem. 2006 Jun;52(6):1200-1.

0(0,0,0,0) Details