Protein Information

Name calmodulin
Synonyms CALM; CAM; CALM 1; CALM 2; CALM 3; CALM1; CALM2; CALM3…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
2153338 Clifton GG, Oelsner D, Anderson CR, Pearce CJ, Wallin JD: The effects of mercuric chloride on calmodulin-mediated Ca2+ transport in rat brain. Am J Med Sci. 1990 Jan;299(1):26-31.
32(0,1,1,2) Details
19546257 Peltz A, Sherwani SI, Kotha SR, Mazerik JN, O'Connor Butler ES, Kuppusamy ML, Hagele T, Magalang UJ, Kuppusamy P, Marsh CB, Parinandi NL: Calcium and calmodulin regulate mercury-induced phospholipase D activation in vascular endothelial cells. Int J Toxicol. 2009 May-Jun;28(3):190-206.

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11346962 Chen TH, Hsu CS, Tsai PJ, Ho YF, Lin NS: Heterotrimeric G-protein and signal transduction in the nematode-trapping fungus Arthrobotrys dactyloides. Planta. 2001 Apr;212(5-6):858-63.


The activation leads to an increase in cytoplasmic Ca2+, activation of calmodulin, and finally the opening of water channels.
1(0,0,0,1) Details
7707359 Shoshan-Barmatz V, Weil S, Meyer H, Varsanyi M, Heilmeyer LM: Endogenous, Ca (2+)-dependent cysteine-protease cleaves specifically the ryanodine receptor/Ca2+ release channel in skeletal muscle. J Membr Biol. 1994 Dec;142(3):281-8.

The activity of this protease is strongly stimulated by dithiothreitol (DTT), cysteine and beta-mercaptoethanol, and is inhibited by iodoacetamide, mercuric chloride and leupeptin, but not by PMSF.
The calpain binding site is identified as a PEST (proline, glutamic acid, serine, threonine-rich) region in the amino acid sequence GTPGGTPQPGVE, at positions 1356-1367 of the RyR and the cleavage site, the calmodulin binding site, at residues 1383-1400.
1(0,0,0,1) Details
7825186 Yamamoto H: A hypothesis for cyanide-induced tonic seizures with supporting evidence. Toxicology. 1995 Jan 6;95(1-3):19-26.

The ED50 value of cyanide as measured by induction of tonic seizures was significantly increased in a dose-dependent manner when mercuric chloride (0.5 or 5.0 nmol/body), gangliosides (GGS) (90 nmol/body), a protein kinase C inhibitor or trifluoperazine (TFP) (45 or 90 nmol/body), a calmodulin inhibitor were preinjected intracerebroventricularly (i.v.t.) and NG-nitro-L-arginine (NNA) (300 mg/kg), a nitric oxide (NO) synthase inhibitor was preinjected intraperitoneally (i.p.) in mice.
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