| Name | fibrillarin |
|---|---|
| Synonyms | 34 kDa nucleolar scleroderma antigen; FIB 1; FIB1; FBL; FBL protein; FIB; FLRN; Fibrillarin… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12388758 | Chen M, Rockel T, Steinweger G, Hemmerich P, Risch J, von Mikecz A: Subcellular recruitment of fibrillarin to nucleoplasmic proteasomes: implications for processing of a nucleolar autoantigen. Mol Biol Cell. 2002 Oct;13(10):3576-87. Because proteasomes are absent from the nucleolus, a recruitment system was used to analyze the molecular fate of nucleolar protein fibrillarin: Subtoxic concentrations of mercuric chloride (HgCl (2)) induce subcellular redistribution of fibrillarin and substantial colocalization (33%) with nucleoplasmic proteasomes in different cell lines and in primary cells isolated from mercury-treated mice. |
34(0,1,1,4) | Details |
| 17084957 | Havarinasab S, Bjorn E, Ekstrand J, Hultman P: Dose and Hg species determine the T-helper cell activation in murine autoimmunity. Toxicology. 2007 Jan 5;229(1-2):23-32. Epub 2006 Sep 24. Inorganic mercury (mercuric chloride--HgCl (2)) induces in mice an autoimmune syndrome (HgIA) with T cell-dependent polyclonal B cell activation and hypergammaglobulinemia, dose- and H-2-dependent production of autoantibodies targeting the 34 kDa nucleolar protein fibrillarin (AFA), and systemic immune-complex deposits. |
31(0,1,1,1) | Details |
| 7529293 | Takeuchi K, Turley SJ, Tan EM, Pollard KM: Analysis of the autoantibody response to fibrillarin in human disease and murine models of autoimmunity. J Immunol. 1995 Jan 15;154(2):961-71. Autoantibodies against fibrillarin can also be induced in H-2s mice by treatment with mercuric chloride (HgCl2). |
14(0,0,1,9) | Details |
| 10685806 | Arnett FC, Fritzler MJ, Ahn C, Holian A: Urinary mercury levels in patients with autoantibodies to U3-RNP (fibrillarin). J Rheumatol. 2000 Feb;27(2):405-10. OBJECTIVE: Autoantibodies to the U3 nucleolar ribonucleoprotein (RNP) fibrillarin occur in some patients with systemic sclerosis (SSc) or other connective tissue diseases and can be induced in certain mouse strains by injections of mercuric chloride, perhaps due to antigenic alteration of fibrillarin by mercury (Hg). |
7(0,0,1,2) | Details |
| 10497068 | Pearson DL, Reimonenq RD, Pollard KM: Expression and purification of recombinant mouse fibrillarin. . Protein Expr Purif. 1999 Oct;17(1):49-56. |
7(0,0,0,7) | Details |
| 7586739 | Hultman P, Ganowiak K, Turley SJ, Pollard KM: Genetic susceptibility to silver-induced anti-fibrillarin autoantibodies in mice. Clin Immunol Immunopathol. 1995 Dec;77(3):291-7. Similar to mercuric chloride, silver has recently been shown to induce IgG autoantibodies targeting the nucleolar 34-kDa protein fibrillarin i SJL (H-2s) mice. |
7(0,0,1,2) | Details |
| 9120314 | Pollard KM, Lee DK, Casiano CA, Bluthner M, Johnston MM, Tan EM: The autoimmunity-inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular and antigenic properties. J Immunol. 1997 Apr 1;158(7):3521-8. |
6(0,0,0,6) | Details |
| 7647579 | Kubicka-Muranyi M, Griem P, Lubben B, Rottmann N, Luhrmann R, Gleichmann E: Mercuric-chloride-induced autoimmunity in mice involves up-regulated presentation by spleen cells of altered and unaltered nucleolar self antigen. Int Arch Allergy Immunol. 1995 Sep;108(1):1-10. HgCl2 treatment of B10.S mice induces IgG autoantibodies to fibrillarin, a component of small nuclear ribonucleoprotein particles, and histone. |
5(0,0,0,5) | Details |
| 10942594 | Chen M, von Mikecz A: Specific inhibition of rRNA transcription and dynamic relocation of fibrillarin induced by mercury. Exp Cell Res. 2000 Aug 25;259(1):225-38. |
5(0,0,0,5) | Details |
| 11580225 | Yang JM, Baserga SJ, Turley SJ, Pollard KM: Fibrillarin and other snoRNP proteins are targets of autoantibodies in xenobiotic-induced autoimmunity. Clin Immunol. 2001 Oct;101(1):38-50. |
4(0,0,0,4) | Details |
| 2612058 | Hultman P, Enestrom S, Pollard KM, Tan EM: Anti-fibrillarin autoantibodies in mercury-treated mice. Clin Exp Immunol. 1989 Dec;78(3):470-7. B10.S mice treated with mercuric chloride consistently developed ANuA, which also targeted a 34-kD nucleolar protein. |
3(0,0,0,3) | Details |
| 10925315 | Pollard KM, Pearson DL, Bluthner M, Tan EM: Proteolytic cleavage of a self-antigen following xenobiotic-induced cell death produces a fragment with novel immunogenic properties. J Immunol. 2000 Aug 15;165(4):2263-70. The heavy metal mercury elicits a genetically restricted autoantibody response in mice that targets the nucleolar autoantigen fibrillarin. |
3(0,0,0,3) | Details |
| 7536297 | Lubben B, Rottmann N, Kubicka-Muranyi M, Gleichmann E, Luhrmann R: The specificity of disease-associated anti-fibrillarin autoantibodies compared with that of HgCl2-induced autoantibodies. Mol Biol Rep. 1994;20(2):63-73. Animal models in which abundant anti-nucleolar antibodies appear spontaneously have not yet been described; however, high levels of anti-fibrillarin antibodies can be induced by treating susceptible strains of mice with sub-toxic amounts of mercuric chloride. |
3(0,0,0,3) | Details |
| 8738957 | Hultman P, Turley SJ, Enestrom S, Lindh U, Pollard KM: Murine genotype influences the specificity, magnitude and persistence of murine mercury-induced autoimmunity. J Autoimmun. 1996 Apr;9(2):139-49. We studied the influence of genotype on systemic autoimmunity by treating female mice of the H-2s strains SJL/N, SJL/J, A.SW, and B10.S with mercuric chloride (HgCl2) for 10 weeks and then following autoantibody and tissue immune deposits during the subsequent 12 months. All strains developed antinucleolar antibodies (ANoA) of the IgG class which reacted in immunoblotting with a 34-kDa nucleolar protein identified as fibrillarin. |
2(0,0,0,2) | Details |
| 2521387 | Reuter R, Tessars G, Vohr HW, Gleichmann E, Luhrmann R: Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice. Proc Natl Acad Sci U S A. 1989 Jan;86(1):237-41. It is a protein with an apparent molecular mass of 36 kDa and a pI value of approximately 8.6, which is associated with the nucleolar small nuclear RNA U3, and by these criteria must be identical with a polypeptide called fibrillarin. |
2(0,0,0,2) | Details |
| 9693280 | Johansson U, Hansson-Georgiadis H, Hultman P: The genotype determines the B cell response in mercury-treated mice. Int Arch Allergy Immunol. 1998 Aug;116(4):295-305. BACKGROUND: Mercury causes in mouse strains of the H-2s haplotype an autoimmune syndrome with antibodies to the nucleolar protein fibrillarin and systemic immune complex (IC) deposits. METHODS: During 4-7 weeks of subcutaneous mercuric chloride injections, the number of B cells and the expression of cell surface activation and proliferation markers was monitored by flow cytometry. |
2(0,0,0,2) | Details |
| 8527945 | Kubicka-Muranyi M, Kremer J, Rottmann N, Lubben B, Albers R, Bloksma N, Luhrmann R, Gleichmann E: Murine systemic autoimmune disease induced by mercuric chloride: T helper cells reacting to self proteins. Int Arch Allergy Immunol. 1996 Jan;109(1):11-20. They hardly reacted to HgCl2 and reacted poorly to Hg-containing splenic proteins, but responded vigorously to nuclei and fibrillarin irrespective of whether these self constituents had been treated with HgCl2 or not. |
2(0,0,0,2) | Details |
| 14616778 | Haggqvist B, Hultman P: Effects of deviating the Th2-response in murine mercury-induced autoimmunity towards a Th1-response. Clin Exp Immunol. 2003 Nov;134(2):202-9. Mercury-induced autoimmunity (HgIA) in mice is an H-2 regulated condition with antinucleolar antibodies targeting fibrillarin (ANoA), systemic immune-complex (IC) deposits and transient polyclonal B-cell activation (PBA). |
1(0,0,0,1) | Details |
| 15036746 | Mellergard J, Havarinasab S, Hultman P: Short- and long-term effects of T-cell modulating agents in experimental autoimmunity. Toxicology. 2004 Mar 15;196(3):197-209. Genetically susceptible (H-2 (s)) mice develop in response to mercury (Hg) a systemic autoimmune condition with antinucleolar antibodies (ANoA) targeting the protein fibrillarin, transient polyclonal B-cell activation, hyperimmunoglobulinemia, and systemic immune-complex (IC) deposits. |
1(0,0,0,1) | Details |
| 9600807 | Hultman P, Nielsen JB: The effect of toxicokinetics on murine mercury-induced autoimmunity. Environ Res. 1998 May;77(2):141-8. Mercury induces autoantibodies to the nucleolar protein fibrillarin (ANoA) in genetically susceptible (H-2AS) mouse strains. |
1(0,0,0,1) | Details |
| 9237798 | Johansson U, Sander B, Hultman P: Effects of the murine genotype on T cell activation and cytokine production in murine mercury-induced autoimmunity. J Autoimmun. 1997 Aug;10(4):347-55. Mercury induces a systemic autoimmune condition characterized by auto-antibodies to the nucleolar protein fibrillarin (AFA) and systemic immune-complex (IC) deposits in genetically susceptible mouse strains. |
1(0,0,0,1) | Details |
| 8816434 | Satoh M, Hamilton KJ, Ajmani AK, Dong X, Wang J, Kanwar YS, Reeves WH: Autoantibodies to ribosomal P antigens with immune complex glomerulonephritis in SJL mice treated with pristane. J Immunol. 1996 Oct 1;157(7):3200-6. In contrast, mercuric chloride induces anti-fibrillarin Abs only in SJL and other H-2s mice, and not in BALB/c (H-2d) mice. |
0(0,0,0,0) | Details |
| 8283044 | Monestier M, Losman MJ, Novick KE, Aris JP: Molecular analysis of mercury-induced antinucleolar antibodies in H-2S mice. J Immunol. 1994 Jan 15;152(2):667-75. In H-2S mice, the administration of mercuric chloride results in the development of antinucleolar autoantibodies. |
0(0,0,0,0) | Details |