| Name | interleukin (protein family or complex) |
|---|---|
| Synonyms | Interleukin; Interleukins; interleukin receptor; interleukin receptors |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11737666 | Bagenstose LM, Mentink-Kane MM, Brittingham A, Mosser DM, Monestier M: Mercury enhances susceptibility to murine leishmaniasis. . Parasite Immunol. 2001 Dec;23(12):633-40. Susceptible mice develop a T-helper type 2 (Th2)-type immune response following infection distinguished by the development of interleukin (IL)-4 secreting T cells in the lymph node and spleen. We show that subtoxic doses of mercuric chloride (HgCl2) exacerbate disease outcome in SJL mice resulting in increased footpad swelling and increased parasite burdens. |
1(0,0,0,1) | Details |
| 18496552 | Li HH, Hsu YH, Wei CC, Lee PT, Chen WC, Chang MS: Interleukin-20 induced cell death in renal epithelial cells and was associated with acute renal failure. Genes Immun. 2008 Jul;9(5):395-404. Epub 2008 May 22. Interleukin (IL)-10 inhibits ischemic and cisplatin-induced acute renal failure. |
1(0,0,0,1) | Details |
| 9135547 | Hu H, Abedi-Valugerdi M, Moller G: Pretreatment of lymphocytes with mercury in vitro induces a response in T cells from genetically determined low-responders and a shift of the interleukin profile. Immunology. 1997 Feb;90(2):198-204. We found that in vitro mercuric chloride induced a high proliferative response in spleen lymphocytes from mercury-susceptible SJL mice, but a low response in resistant mice, such as C57BL/6 (H-2b), A/J (H-2a) and CBA (H-2k) mice. |
1(0,0,0,1) | Details |
| 9405450 | Badou A, Savignac M, Moreau M, Leclerc C, Pasquier R, Druet P, Pelletier L: HgCl2-induced interleukin-4 gene expression in T cells involves a protein kinase C-dependent influx through L-type channels. J Biol Chem. 1997 Dec 19;272(51):32411-8. Mercuric chloride (HgCl2) induces T helper 2 (Th2) autoreactive anti-class II T cells in Brown Norway rats. These cells produce interleukin (IL)-4 and induce a B cell polyclonal activation that is responsible for autoimmune disease. |
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| 11934688 | Miyaji T, Hu X, Star RA: alpha-Melanocyte-simulating hormone and interleukin-10 do not protect the kidney against mercuric chloride-induced injury. Am J Physiol Renal Physiol. 2002 May;282(5):F795-801. |
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| 11359392 | Little MC, Watson RE, Pemberton MN, Griffiths CE, Thornhill MH: Activation of oral keratinocytes by mercuric chloride: relevance to dental amalgam-induced oral lichenoid reactions. Br J Dermatol. 2001 May;144(5):1024-32. |
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| 7664789 | Oliveira DB, Gillespie K, Wolfreys K, Mathieson PW, Qasim F, Coleman JW: Compounds that induce autoimmunity in the brown Norway rat sensitize mast cells for mediator release and interleukin-4 expression. Eur J Immunol. 1995 Aug;25(8):2259-64. Brown Norway (BN) rats given mercuric chloride (HgCl2), gold (Au) salts or D-penicillamine develop a T helper 2 (Th2) cell-mediated autoimmune syndrome. |
0(0,0,0,0) | Details |
| 8258322 | Saoudi A, Kuhn J, Huygen K, de Kozak Y, Velu T, Goldman M, Druet P, Bellon B: TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoimmune disease. Eur J Immunol. 1993 Dec;23(12):3096-103. Mercuric chloride (HgCl2) injections protect Brown-Norway) F1 (F1) rats against experimental autoimmune uveoretinitis (EAU) induced by immunization with the retinal S antigen (S-Ag); in contrast HgCl2-injected F1 rats develop EAU following transfer of lymph node (LN) cells from rats immunized with S-Ag alone. |
0(0,0,0,0) | Details |
| 10447925 | Szeto C, Gillespie KM, Mathieson PW: Low-dose mercuric chloride induces resistance in brown norway rats to further mercuric chloride by up-regulation of interferon-gamma. Scand J Immunol. 1999 Aug;50(2):195-201. |
0(0,0,0,0) | Details |
| 14738445 | Wu Z, Holwill SD, Oliveira DB: Desferrioxamine modulates chemically induced T helper 2-mediated autoimmunity in the rat. Clin Exp Immunol. 2004 Feb;135(2):194-9. A rise in interleukin (IL) 4-dependent immunoglobulin E (IgE) is a hallmark of the mercuric chloride (HgCl2)-induced Th2-mediated autoimmune syndrome in the Brown Norway (BN) rat, and one of the mediators in allergic asthma in human. |
31(0,1,1,1) | Details |
| 17302730 | Hemdan NY, Lehmann I, Wichmann G, Lehmann J, Emmrich F, Sack U: Immunomodulation by mercuric chloride in vitro: application of different cell activation pathways. Clin Exp Immunol. 2007 May;148(2):325-37. Epub 2007 Feb 14. In MoAb-stimulated cells, interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 production was reduced. |
1(0,0,0,1) | Details |
| 15588918 | Ringerike T, Ulleras E, Volker R, Verlaan B, Eikeset A, Trzaska D, Adamczewska V, Olszewski M, Walczak-Drzewiecka A, Arkusz J, van Loveren H, Nilsson G, Lovik M, Dastych J, Vandebriel RJ: Detection of immunotoxicity using T-cell based cytokine reporter cell lines ("Cell Chip"). Toxicology. 2005 Jan 15;206(2):257-72. We used this prototype "Cell Chip" to test, by means of flow cytometry, the immunomodulatory potential of 13 substances and were able to detect changes in cytokine expression in 12 cases (successful for cyclosporine, rapamycin, pentamidine, thalidomide, bis (tri-n-butyltin) oxide, house dust mite allergen (Der p I), 1-chloro-2,4-dinitrobenzene, tolylene 2,4-diisocyanate, tetrachloroplatinate, and mercuric chloride; unsuccessful for penicillin G). The T-cell lymphoma cell line EL-4 was transfected with the regulatory sequences of interleukin (IL)-2, IL-4, IL-10, interferon (IFN)-gamma or actin fused to the gene for enhanced green fluorescent protein (EGFP) in either a stabile or a destabilised form. |
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| 19604304 | Wu Z, Pearson A, Oliveira D: Characterization of cis-regulatory elements conferring mercury-induced interleukin-4 gene expression in rat mast cells: a role for signal transducer and activator of transcription 6 and TATA box binding sites. Immunology. 2009 Aug;127(4):530-8. We have previously shown that oxidative stress is involved in the pathogenesis of a mercuric chloride (HgCl (2))-induced, T helper type 2 (Th2)-driven autoimmune syndrome in Brown Norway (BN) rats. In the context of the syndrome, the oxidative stress-induced mast cell response seems to determine the development of the early phase of vasculitis, while oxidative stress-mediated interleukin (IL)-4 production may contribute to the subsequent Th2-driven autoimmune response. |
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| 7647579 | Kubicka-Muranyi M, Griem P, Lubben B, Rottmann N, Luhrmann R, Gleichmann E: Mercuric-chloride-induced autoimmunity in mice involves up-regulated presentation by spleen cells of altered and unaltered nucleolar self antigen. Int Arch Allergy Immunol. 1995 Sep;108(1):1-10. Four fibrillarin-specific hybridoma clones studied for cytokine production were shown to produce interleukin (IL)-2, and three of them also produced IL-4. |
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