| Name | glutathione S transferase |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12180707 | Ferrat L, Romeo M, Gnassia-Barelli M, Pergent-Martini C: Effects of mercury on antioxidant mechanisms in the marine phanerogam Posidonia oceanica. Dis Aquat Organ. 2002 Jul 8;50(2):157-60. Biochemical markers of oxidative stress such as catalase activity, glutathione S-transferase (GST) activity and levels of lipid peroxidation evaluated in terms of thiobarbituric acid reactive substances (TBARS) were measured in the sheaths of the marine phanerogam Posidonia oceanica (L.) Delile experimentally exposed to 0.01, 0.1 and 1 microgHg l (-1) for 48 h. |
1(0,0,0,1) | Details |
| 9434069 | McGuire S, Daggett DA, Bostad E, Nelson S, Wright LS, Siegel FL, Kornguth S: Increased levels of glutathione S transferases and appearance of novel alpha class isoenzymes in kidneys of mice exposed to mercuric chloride. Nephron. 1997;77(4):452-60. |
7(0,0,1,2) | Details |
| 17706852 | Sharma MK, Sharma A, Kumar A, Kumar M: Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice. Food Chem Toxicol. 2007 Dec;45(12):2412-9. Epub 2007 Jun 28. The activities of antioxidants enzymes superoxide dismutase, catalase and glutathione-S-transferase were also concomitantly restored to near normal level by Spirulina supplementation to mercuric chloride intoxicated mice. |
6(0,0,1,1) | Details |
| 11036982 | Cursino L, Mattos SV, Azevedo V, Galarza F, Bucker DH, Chartone-Souza E, Nascimento A: Capacity of mercury volatilization by mer (from Escherichia coli) and glutathione S-transferase (from Schistosoma mansoni) genes cloned in Escherichia coli. Sci Total Environ. 2000 Oct 16;261(1-3):109-13. This method enabled strains containing simultaneously mer and glutathione S-transferase genes to grow in high concentrations of mercuric chloride (30 microg/ml) and to volatilize part of the mercury (248 microg/g cell dry wt.) present in the culture medium, while strains bearing only a single gene, did not have the same behavior. |
3(0,0,0,3) | Details |
| 2386429 | Bomhard E, Maruhn D, Vogel O, Mager H: Determination of urinary glutathione S-transferase and lactate dehydrogenase for differentiation between proximal and distal nephron damage. Arch Toxicol. 1990;64(4):269-78. To test this hypothesis, we determined both enzyme activities in 24 h urine samples from 10-12 female Sprague-Dawley rats, each treated with single i.p. injections of puromycin aminonucleoside (PAN, 130 mg/kg), Na2 CrO4 10, 20, 30 mg/kg), mercuric chloride (HgCl2, 0.5, 0.75, 1.0 mg/kg), (125, 350, 375 mg/kg), ethyleneimine (0.5, 2.0, 5.0 microliters/kg). |
2(0,0,0,2) | Details |
| 12151111 | Shin YH, Park EH, Fuchs JA, Lim CJ: Characterization, expression and regulation of a third gene encoding glutathione S-transferase from the fission yeast. Biochim Biophys Acta. 2002 Aug 19;1577(1):164-70. The cloned GSTIII gene caused higher survivals of S. pombe cells on solid media with cadmium or mercuric chloride. |
2(0,0,0,2) | Details |
| 11997110 | Cho YW, Park EH, Fuchs JA, Lim CJ: A second stress-inducible glutathione S-transferase gene from Schizosaccharomyces pombe. Biochim Biophys Acta. 2002 Apr 12;1574(3):399-402. The synthesis of beta-galactosidase from the fusion plasmid is greatly enhanced by the treatments with oxidative stresses such as and mercuric chloride. |
2(0,0,0,2) | Details |
| 11513961 | Kim HG, Park KN, Cho YW, Park EH, Fuchs JA, Lim CJ: Characterization and regulation of glutathione S-transferase gene from Schizosaccharomyces pombe. Biochim Biophys Acta. 2001 Aug 30;1520(2):179-85. In a culture of S. pombe containing plasmid pGT207, the growth was inhibited less by mercuric chloride than in a culture with vector alone. |
2(0,0,0,2) | Details |
| 11495025 | El-Demerdash FM: Effects of and mercury on the enzymatic activities and lipid peroxidation in brain, liver, and blood of rats. J Environ Sci Health B. 2001 Jul;36(4):489-99. The present study compares the effects of Se as selenite (Na2SeO3) and Hg as mercuric chloride (HgCl2) separately and in combination. The following biochemical alterations occurred in response to Hg treatment: protein content (brain and liver), acetylcholinesterase (AChE) (brain and serum), acid and alkaline (AcP and AlP) phosphatases (plasma and liver) and glutathione S-transferase (GST) (plasma and liver) activities were significantly (P <0.05) decreased, while lactate dehydrogenase (LDH) (plasma, brain and liver), and alanine aminotransferase (AST, ALT) (serum and liver) activities were significantly increased. |
1(0,0,0,1) | Details |
| 19382722 | Zhao JQ, Wen YF, Bhadauria M, Nirala SK, Sharma A, Shrivastava S, Shukla S, Agrawal OP, Mathur R: Protective effects of propolis on inorganic mercury induced oxidative stress in mice. Indian J Exp Biol. 2009 Apr;47(4):264-9. Exposure to mercuric chloride (HgCl2; 5 mg/kg; ip) induced oxidative stress by increasing lipid peroxidation and level along with concomitant decrease in and various antioxidant enzymes. Activities of antioxidants enzymes, i.e., superoxide dismutase, catalase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase were also restored concomitantly towards control after propolis administration. |
1(0,0,0,1) | Details |
| 19636703 | Monteiro DA, Rantin FT, Kalinin AL: Inorganic mercury exposure: toxicological effects, oxidative stress biomarkers and bioaccumulation in the tropical freshwater fish matrinxa, Brycon amazonicus (Spix and Agassiz, 1829). Ecotoxicology. 2010 Jan;19(1):105-23. Epub 2009 Jul 28. Increases in superoxide dismutase, catalase, peroxidase (GPx), glutathione S-transferase (GST) and glutathione reductase (GR) were observed in all tissues after HgCl (2) exposure, except for white muscle GR activity and hepatic GPx. |
1(0,0,0,1) | Details |
| 19406194 | Brandao R, Borges LP, Nogueira CW: Concomitant administration of 2,3-dimercapto-1-propanesulphonate (DMPS) and diphenyl diselenide reduces effectiveness of DMPS in restoring damage induced by mercuric chloride in mice. Food Chem Toxicol. 2009 Aug;47(8):1771-8. Epub 2009 May 3. Thiobarbituric acid-reactive substances (TBARS), and Hg (2+) levels and glutathione S-transferase (GST) and catalase (CAT) activities were carried out in kidney. |
1(0,0,0,1) | Details |
| 10696784 | Matsuoka M, Wispriyono B, Iryo Y, Igisu H: Mercury activates c-Jun N-terminal kinase and induces c-jun expression in LLC-PK1 cells. Toxicol Sci. 2000 Feb;53(2):361-8. When exposed to 10 or 20 microM HgCl2, the level of phosphorylated JNK and the activity of JNK assayed in vitro using glutathione-S-transferase-c-Jun as substrate increased markedly. |
1(0,0,0,1) | Details |
| 12928767 | Mahieu ST, Gionotti M, Millen N, Elias MM: Effect of chronic accumulation of aluminum on renal function, cortical renal oxidative stress and cortical renal organic anion transport in rats. Arch Toxicol. 2003 Nov;77(11):605-12. Epub 2003 Aug 20. The renal cortex was separated and homogenized to determine (GSH) level, glutathione S-transferase (GST) activity and lipid peroxidation (LPO) level. |
1(0,0,0,1) | Details |
| 19720107 | Stacchiotti A, Morandini F, Bettoni F, Schena I, Lavazza A, Grigolato PG, Apostoli P, Rezzani R, Aleo MF: Stress proteins and oxidative damage in a renal derived cell line exposed to inorganic mercury and lead. Toxicology. 2009 Oct 29;264(3):215-24. Epub 2009 Aug 29. In particular, as biochemical indicators of oxidative stress we detected reactive species (ROS) and species (RNS), total (GSH) and glutathione-S-transferase (GST) activity. |
1(0,0,0,1) | Details |
| 16327069 | Arabi M, Alaeddini MA: Metal-ion-mediated oxidative stress in the gill homogenate of rainbow trout (Oncorhynchus mykiss): antioxidant potential of and albumin. Biol Trace Elem Res. 2005 Winter;108(1-3):155-68. This study was undertaken to evaluate the effects of and mercury at the 400- to 1000-microM concentration range on some biochemical markers of oxidative stress, such as lipid peroxidation (LPO), glutathione-S-transferase (GST) activity, and (GSH) content in the rainbow trout gill homogenates with or without supplementation of manganese, selenium, and bovine serum albumin (BSA). |
1(0,0,0,1) | Details |
| 12215206 | Shenker BJ, Pankoski L, Zekavat A, Shapiro IM: Mercury-induced apoptosis in human lymphocytes: caspase activation is linked to redox status. Antioxid Redox Signal. 2002 Jun;4(3):379-89. Real-time RT-PCR analysis demonstrated a significant reduction in both glutathione S-transferase and peroxidase gene expression in mercury-treated cells. We have previously shown that methyl mercuric chloride (MeHgCl) is a potent human T-cell apoptogen; moreover, mitochondria appear to be a target organelle for the induction of cell death. |
1(0,0,0,1) | Details |
| 12521308 | Lim CJ, Cho YW, Sa JH, Lim HW, Kim HG, Kim SJ, Park EH: Pap1-dependent regulation of the GSTII gene from the fission yeast. Mol Cells. 2002 Dec 31;14(3):431-6. The genomic DNA encoding a second glutathione S-transferase (GSTII) was previously isolated from the fission yeast Schizosaccharomyces pombe. Its expression was shown to be induced by mercuric chloride, o-dinitrobenzene, and NO-generating S-nitroso-N-acetylpenicillamine using the GSTII-lacZ fusion harboring the 910 bp upstream region from the translational initiation point. |
1(0,0,0,1) | Details |
| 12389915 | Ferrat L, Bingert A, Romeo M, Gnassia-Barelli M, Pergent-Martini C: Mercury uptake and enzymatic response of Posidonia oceanica after an experimental exposure to organic and inorganic forms. Environ Toxicol Chem. 2002 Nov;21(11):2365-71. The aim of this study was to examine the experimental uptake of mercury and the enzymatic response, i.e., glutathione S-transferase (GST) activity, to this metal introduced into the medium under organic (methylmercury and nonorganic (mercury forms. |
1(0,0,0,1) | Details |