Protein Information

Name lysozyme
Synonyms LYZ; LZM; Lysozyme; Lysozyme C; Lysozyme C precursor; Lysozymes; Lysozyme Cs; Lysozyme C precursors

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
7742640 Low KW, Sin YM: Effects of mercuric chloride on chemiluminescent response of phagocytes and tissue lysozyme activity in tilapia, Oreochromis aureus. Bull Environ Contam Toxicol. 1995 Feb;54(2):302-8.
6(0,0,1,1) Details
1922612 Houser MT, Milner LS: Renal tubular protein handling in experimental renal disease. . Nephron. 1991;58(4):461-5.

The present study evaluated renal lysozyme and albumin handling following renal tubular injury induced by both low- and high-dose mercuric chloride (0.5 and 2.0 mg/kg) and maleic acid (50 and 400 mg/kg), and following glomerular injury induced by puromycin aminonucleoside (5 mg/100 g) or Adriamycin (5 mg/kg).
6(0,0,1,1) Details
3449639 Ohata H, Momose K, Takahashi A, Omori Y: Urinalysis for detection of chemically induced renal damage (1)--Changes in urinary excretions of enzymes and various components caused by mercuric chloride and gentamicin. J Toxicol Sci. 1987 Nov;12(4):341-55.

Daily administration of mercuric chloride (HgCl2) dose-dependently increased urinary excretions of lactate dehydrogenase (LDH), aspartate aminotransferase (GOT), alkaline phosphatase (ALP), leucine aminopeptidase (LAP), lysozyme (LZM), N-acetyl-beta-D-glucosaminidase (NAG), and acid protease together with increased counts of tubular cells in the urine.
6(0,0,1,1) Details
9646523 Low KW, Sin YM: Effects of mercuric chloride and sodium selenite on some immune responses of blue gourami, Trichogaster trichopterus (Pallus). Sci Total Environ. 1998 Jun 18;214:153-64.

These include tissue lysozyme activity, kidney lymphocyte proliferation and plasma agglutinating antibody titre against bacteria.
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8343601 Margis-Pinheiro M, Martin C, Didierjean L, Burkard G: Differential expression of bean chitinase genes by virus infection, chemical treatment and UV irradiation. Plant Mol Biol. 1993 Jul;22(4):659-68.

We have also determined the complete nucleotide sequence of the cDNA encoding P3-chitinase that has been isolated from a cDNA library by using the cucumber lysozyme-chitinase cDNA as a probe.
Time course studies of mRNA accumulation of two of them (P3- and P4-chitinases) have been studied upon virus infection, mercuric chloride treatment and UV irradiation.
2(0,0,0,2) Details
10752156 Lapirova TB, Mikriakov VR, Mavrin AS, Vinogradov GA: [Effect of sublethal concentrations of mercury, cadmium, and copper salts on the lysozyme level in tissues from the Lena sturgeon Asipenser baeri brood] Zh Evol Biokhim Fiziol. 2000 Jan-Feb;36(1):37-9.

1(0,0,0,1) Details
8095245 Jonker D, Jones MA, van Bladeren PJ, Woutersen RA, Til HP, Feron VJ: Acute (24 hr) toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of the individual compounds. Food Chem Toxicol. 1993 Jan;31(1):45-52.

To identify possible hazards of combined exposure to chemicals with the same target organ, a 24-hr single dose experiment was carried out in which the renal toxicity of mercuric chloride, potassium dichromate, d-limonene and hexachloro-1:3-butadiene administered simultaneously was compared with the nephrotoxicity of the individual compounds, using a total of 11 groups each consisting of five 12-wk-old male Wistar rats.
Synergism of effects was also observed, for example increased severity of renal tubular necrosis, and more markedly increased activity of urinary lysozyme, lactate dehydrogenase, alkaline phosphatase and N-acetyl-beta-glucosaminidase.
1(0,0,0,1) Details
3190458 Ohata H, Hashimoto T, Monose K, Takahashi A, Terao T: Urinalysis for detection of chemically induced renal damage (3)--Establishment and application of radioimmunoassay for lysozyme of rat urine. Arch Toxicol. 1988 Aug;62(1):60-5.

Using the RIA, it was ascertained that urinary LZM excretion began to increase on day 5 in rats treated with gentamicin (15 or 30 mg/kg/day sc for 17 days), during the 6-9 h period in the rats treated with mercuric chloride (1 mg/kg sc), and during the 0-3 h period in the rats treated with p-aminophenol (1 mmol/kg sc).
2(0,0,0,2) Details
12077427 Sun PD, Radaev S, Kattah M: Generating isomorphous heavy-atom derivatives by a quick-soak method. Acta Crystallogr D Biol Crystallogr. 2002 Jul;58(Pt 7):1092-8. Epub 2002 Jun 20.


Using lysozyme and FcgammaRIII receptor crystals as test cases, an improved soaking method for the generation of conventional heavy-atom derivatives has been developed.
1(0,0,0,1) Details
3394153 Baginski B: Effect of mercuric chloride on microbicidal activities of human polymorphonuclear leukocytes. Toxicology. 1988 Aug;50(3):247-56.

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1501744 Houser MT, Milner LS, Kolbeck PC, Wei SH, Stohs SJ: Glutathione monoethyl ester moderates mercuric chloride-induced acute renal failure. Nephron. 1992;61(4):449-55.

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