| Name | protein kinase C (protein family or complex) |
|---|---|
| Synonyms | Protein kinase C; PKC |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9405450 | Badou A, Savignac M, Moreau M, Leclerc C, Pasquier R, Druet P, Pelletier L: HgCl2-induced interleukin-4 gene expression in T cells involves a protein kinase C-dependent influx through L-type channels. J Biol Chem. 1997 Dec 19;272(51):32411-8. Mercuric chloride (HgCl2) induces T helper 2 (Th2) autoreactive anti-class II T cells in Brown Norway rats. |
2(0,0,0,2) | Details |
| 2255679 | Lison D, Raguzzi F, Lauwerys R: Comparison of the effects of auranofin, heavy metals and retinoids on protein kinase C in vitro and on a protein kinase C mediated response in macrophages. Pharmacol Toxicol. 1990 Sep;67(3):239-42. In vitro, and in absence of chelators, mercuric chloride is also a potent inhibitor of PKC. |
1(0,0,0,1) | Details |
| 11832426 | Notenboom S, Miller DS, Smits P, Russel FG, Masereeuw R: Role of NO in endothelin-regulated drug transport in the renal proximal tubule. Am J Physiol Renal Physiol. 2002 Mar;282(3):F458-64. We previously demonstrated in intact killifish renal proximal tubules that endothelin (ET), acting through an ET (B) receptor and protein kinase C (PKC), reduced transport mediated by multidrug resistance-associated protein 2 (Mrp2), i.e., luminal accumulation of fluorescein methotrexate (FL-MTX) (Masereeuw R, Terlouw SA, Van Aubel RAMH, Russel FGM, and Miller DS. |
1(0,0,0,1) | Details |
| 11104828 | Matsuoka M, Wispriyono B, Iryo Y, Igisu H, Sugiura T: Inhibition of HgCl2-induced mitogen-activated protein kinase activation by LL-Z1640-2 in CCRF-CEM cells. Eur J Pharmacol. 2000 Dec 8;409(2):155-8. Exposure of HgCl2 to CCRF-CEM human lymphoblastoid cells induced phosphorylation of mitogen-activated protein kinases (MAPKs); extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK) and p38. |
1(0,0,0,1) | Details |
| 2829391 | Lison D, Dubois P, Lauwerys R: In vitro effect of mercury and on production and plasminogen activator activity of mouse peritoneal macrophages. Toxicol Lett. 1988 Jan;40(1):29-36. The in vitro effects of mercuric chloride and vanadate were examined on two functions of mouse peritoneal macrophages, i.e., the production and the plasminogen activator (PA) activity. |
0(0,0,0,0) | Details |
| 3413030 | Inoue Y, Saijoh K, Sumino K: Action of mercurials on activity of partially purified soluble protein kinase C from mice brain. Pharmacol Toxicol. 1988 May;62(5):278-81. The enzymatic activity of soluble protein kinase C from mice brain was inhibited by mercuric chloride (II) (HgCl2) and organic mercurials, i.e. methyl mercury, phenyl mercury and p-chloromercuribenzoic acid (PCMB). |
84(1,1,1,4) | Details |
| 7825186 | Yamamoto H: A hypothesis for -induced tonic seizures with supporting evidence. Toxicology. 1995 Jan 6;95(1-3):19-26. The ED50 value of as measured by induction of tonic seizures was significantly increased in a dose-dependent manner when mercuric chloride (0.5 or 5.0 nmol/body), gangliosides (GGS) (90 nmol/body), a protein kinase C inhibitor or trifluoperazine (TFP) (45 or 90 nmol/body), a calmodulin inhibitor were preinjected intracerebroventricularly (i.v.t.) and NG-nitro- (NNA) (300 mg/kg), a (NO) synthase inhibitor was preinjected intraperitoneally (i.p.) in mice. |
32(0,1,1,2) | Details |
| 11259864 | Toimela TA, Tahti H: Effects of mercuric chloride exposure on the uptake by cultured retinal pigment epithelial cells. Toxicol In Vitro. 2001 Feb;15(1):7-12. The cytotoxicity caused by 15 min of exposure to mercuric chloride (0.01--1000 microM) was evaluated by WST-1 assay based on the activity of mitochondrial dehydrogenases. [(3) H] uptake was measured after the cells were exposed to 0.1--100 microM mercuric chloride and the selected regulators of protein kinase C (PKC) pathway: PKC activator SC10, PKC inhibitor chelerythrine phospholipase A (2)/C inhibitor manoalide, kinase inhibitor lavendustin A, competitive NMDA receptor antagonist AP7 and IP (3) receptor antagonist |
31(0,1,1,1) | Details |
| 10447931 | McCabe MJ Jr, Santini RP, Rosenspire AJ: Low and nontoxic levels of ionic mercury interfere with the regulation of cell growth in the WEHI-231 B-cell lymphoma. Scand J Immunol. 1999 Sep;50(3):233-41. WEHI-231 is a mouse B-cell line, which is a well-established model for studying signal transduction in B lymphocytes, normally responding to cross-linking of the B-cell receptor (BCR) complex by the rapid upregulation of protein tyrosine kinase activity, followed by increased intracellular and activation of protein kinase C. |
2(0,0,0,2) | Details |