Protein Information

Name cathepsin L
Synonyms CATL; MEP; CTSL; CTSL protein; Cathepsin L; Cathepsin L precursor; Cathepsin L splice variant; Major excreted protein…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
1426527 Reddy GK, Dhar SC: Purification and characterization of collagenolytic property of renal cathepsin L from arthritic rat. Int J Biochem. 1992 Sep;24(9):1465-73.

This enzyme was strongly inhibited by iodoacetate, p-chloromercurobenzoate, mercuric chloride but not inhibited by pepstatin or PMSF.
9(0,0,0,9) Details
15986368 Pacheco FJ, Servin J, Dang D, Kim J, Molinaro C, Daniels T, Brown-Bryan TA, Imoto-Egami M, Casiano CA: Involvement of lysosomal cathepsins in the cleavage of DNA topoisomerase I during necrotic cell death. Arthritis Rheum. 2005 Jul;52(7):2133-45.


The intracellular localization of cathepsin L activity and topo I in necrotic cells was examined using fluorescence microscopy.
3(0,0,0,3) Details
3348813 McDonald JK, Kadkhodayan S: Cathepsin L--a latent proteinase in guinea pig sperm. . Biochem Biophys Res Commun. 1988 Mar 15;151(2):827-35.

2(0,0,0,2) Details