| Name | gamma glutamylcysteine synthetase |
|---|---|
| Synonyms | GCLM; GCS light chain; GLCLR; Gamma ECS; Gamma glutamylcysteine synthetase; Gamma glutamylcysteine synthetase regulatory subunit; Glutamate cysteine ligase modifier subunit; Glutamate cysteine ligase regulatory subunit… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2386541 | Naganuma A, Anderson ME, Meister A: Cellular glutathione as a determinant of sensitivity to mercuric chloride toxicity. Biochem Pharmacol. 1990 Aug 15;40(4):693-7. Depletion of (GSH) by treatment of mice with buthionine sulfoximine (BSO), an effective inhibitor of gamma-glutamylcysteine synthetase, markedly enhanced (about 10-fold) the lethal and renal toxicity of mercuric chloride. |
31(0,1,1,1) | Details |
| 16806635 | Preveral S, Ansoborlo E, Mari S, Vavasseur A, Forestier C: Metal (loid) s and radionuclides cytotoxicity in Saccharomyces cerevisiae. Biochimie. 2006 Nov;88(11):1651-63. Epub 2006 Jun 19. In the presence of heavy metals, application of buthionine sulfoximine (BSO), a well-known inhibitor of gamma-glutamylcysteine synthetase, led to a decrease in the cytosolic pool of GSH and to a limitation of yeast growth. |
1(0,0,0,1) | Details |
| 8806046 | Lash LH, Zalups RK: Alterations in renal cellular glutathione metabolism after in vivo administration of a subtoxic dose of mercuric chloride. J Biochem Toxicol. 1996;11(1):1-9. PT cells were studied as the presumed target site for Hg2+, and DT cells were investigated as a nontarget cell population. gamma-Glutamylcysteine synthetase activity increased after exposure to Hg2+ in PT cells when expressed on cell basis. |
1(0,0,0,1) | Details |
| 11816031 | Westwater J, McLaren NF, Dormer UH, Jamieson DJ: The adaptive response of Saccharomyces cerevisiae to mercury exposure. Yeast. 2002 Feb;19(3):233-9. Expression of the yeast GSH1 gene, encoding gamma-glutamylcysteine synthetase, is known to be regulated by peroxide; in this study we show that expression of a GSH1-lacZ reporter gene is shown to be regulated by exposure to heavy metals, such as mercury and cadmium. |
1(0,0,0,1) | Details |
| 11874199 | Lee YW, Ha MS, Kim YK: Role of reactive species and in inorganic mercury-induced injury in human glioma cells. Neurochem Res. 2001 Nov;26(11):1187-93. Incubation of cells with 0.2 mM buthionine sulfoximine for 24 hr, a selective inhibitor of gamma-glutamylcysteine synthetase, resulted in 56% reduction in GSH content without any change in cell viability. |
1(0,0,0,1) | Details |
| 12787490 | Kim SJ, Shin YH, Kim K, Park EH, Sa JH, Lim CJ: Regulation of the gene encoding glutathione synthetase from the fission yeast. J Biochem Mol Biol. 2003 May 31;36(3):326-31. Interestingly, gamma-glutamylcysteine synthetase activity increased 2.1-fold in the S. pombe cells that contained the cloned GS gene. The S. pombe cells that harbored the multicopy-number plasmid pRGS49 (containing the cloned GS gene) showed a higher level of survival on solid media with cadmium (1 mM) or mercuric chloride (10 microM) than the cells that harbored the YEp357R vector. |
1(0,0,0,1) | Details |