| Name | caspases (protein family or complex) |
|---|---|
| Synonyms | caspase; caspases |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9388494 | Li J, Billiar TR, Talanian RV, Kim YM: reversibly inhibits seven members of the caspase family via S-nitrosylation. Biochem Biophys Res Commun. 1997 Nov 17;240(2):419-24. |
3(0,0,0,3) | Details |
| 17950395 | Laiosa MD, Eckles KG, Langdon M, Rosenspire AJ, McCabe MJ Jr: Exposure to inorganic mercury in vivo attenuates extrinsic apoptotic signaling in Staphylococcal aureus enterotoxin B stimulated T-cells. Toxicol Appl Pharmacol. 2007 Dec 15;225(3):238-50. Epub 2007 Jun 19. To test this hypothesis, BALB/cJ mice were exposed to 10 mg/l mercuric chloride (HgCl (2)) in their drinking water for 2 weeks followed by injection with 20 microg of the Staphylococcal aureus enterotoxin B (SEB) superantigen. The attenuated caspase activity in Hg-exposed mice persisted for 48 h after exposure. |
3(0,0,0,3) | Details |
| 12504520 | Issa Y, Watts DC, Duxbury AJ, Brunton PA, Watson MB, Waters CM: Mercuric chloride: toxicity and apoptosis in a human oligodendroglial cell line MO3.13. Biomaterials. 2003 Mar;24(6):981-7. Biochemical analysis showed that HgCl (2) activated the caspase family of proteases. |
2(0,0,0,2) | Details |
| 15986368 | Pacheco FJ, Servin J, Dang D, Kim J, Molinaro C, Daniels T, Brown-Bryan TA, Imoto-Egami M, Casiano CA: Involvement of lysosomal cathepsins in the cleavage of DNA topoisomerase I during necrotic cell death. Arthritis Rheum. 2005 Jul;52(7):2133-45. METHODS: Topo I cleavage during necrosis was assessed by immunoblotting of lysates from L929 fibroblasts exposed to tumor necrosis factor alpha (TNFalpha) and the broad caspase inhibitor Z-VAD-FMK, and by immunoblotting of lysates from endothelial cells treated with HgCl2. |
2(0,0,0,2) | Details |
| 12215206 | Shenker BJ, Pankoski L, Zekavat A, Shapiro IM: Mercury-induced apoptosis in human lymphocytes: caspase activation is linked to redox status. Antioxid Redox Signal. 2002 Jun;4(3):379-89. We have previously shown that methyl mercuric chloride (MeHgCl) is a potent human T-cell apoptogen; moreover, mitochondria appear to be a target organelle for the induction of cell death. |
2(0,0,0,2) | Details |
| 15050407 | Kim SH, Sharma RP: Mercury-induced apoptosis and necrosis in murine macrophages: role of -induced reactive species and p38 mitogen-activated protein kinase signaling. Toxicol Appl Pharmacol. 2004 Apr 1;196(1):47-57. P38-mediated caspase activation regulates mercury-induced apoptosis and p38-mediated TNFalpha regulates necrosis in these cells. The cytotoxic EC (50) of mercury ranged from 62.7 to 81.1 microM by various assays in J774A.1 cultures; accordingly, we employed 70 microM of mercuric chloride in most experiments. |
1(0,0,0,1) | Details |
| 12505371 | Araragi S, Kondoh M, Kawase M, Saito S, Higashimoto M, Sato M: Mercuric chloride induces apoptosis via a mitochondrial-dependent pathway in human leukemia cells. Toxicology. 2003 Feb 14;184(1):1-9. The release of cytochrome c (Cyt c) from mitochondria into the cytosol, which is an initiator of the activation of caspase cascades, was also observed in HgCl (2)-treated HL-60 cells. |
1(0,0,0,1) | Details |
| 14551197 | Shivakrupa R, Radha V, Sudhakar Ch, Swarup G: Physical and functional interaction between Hck kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain. J Biol Chem. 2003 Dec 26;278(52):52188-94. Epub 2003 Oct 9. These results suggest that C3G and Hck interact physically and functionally in vivo to activate kinase-dependent and caspase-mediated apoptosis, which is independent of catalytic domain of C3G. Phosphorylation of endogenous C3G at Tyr-504 was increased by treatment of human myelomonocytic THP-1 cells with mercuric chloride, which is known to activate Hck kinase specifically. |
1(0,0,0,1) | Details |