Protein Information

Name AQP3
Synonyms AQP 3; AQP3; Aquaporin 3; GIL; aquaporin 3 (GIL blood group); aquaporin 3 (Gill blood group); Aquaporin 3s; aquaporin 3 (GIL blood group)s…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
9374739 Tanaka M, Inase N, Fushimi K, Ishibashi K, Ichioka M, Sasaki S, Marumo F: Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line. Am J Physiol. 1997 Nov;273(5 Pt 1):L1090-5.

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9369468 Kuwahara M, Gu Y, Ishibashi K, Marumo F, Sasaki S: Mercury-sensitive residues and pore site in AQP3 water channel. Biochemistry. 1997 Nov 18;36(46):13973-8.

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12234316 Lai KN, Leung JC, Chan LY, Tang S, Li FK, Lui SL, Chan TM: Expression of aquaporin-3 in human peritoneal mesothelial cells and its up-regulation by glucose in vitro. Kidney Int. 2002 Oct;62(4):1431-9.

Glucose at a concentration of 200 mmol induced glycerol flux by 4.82-fold above the control value (P < 0.0001) and its effect was significantly inhibited by mercuric chloride (P < 0.01).
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11035042 Yang B, Ma T, Verkman AS: Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J Biol Chem. 2001 Jan 5;276(1):624-8.

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19109372 Watanabe S, Hirano T, Grau EG, Kaneko T: Osmosensitivity of prolactin cells is enhanced by the water channel aquaporin-3 in a euryhaline Mozambique tilapia (Oreochromis mossambicus). Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R446-53. Epub 2008 Dec 24.

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19513079 Ismail M, Bokaee S, Morgan R, Davies J, Harrington KJ, Pandha H: Inhibition of the aquaporin 3 water channel increases the sensitivity of prostate cancer cells to cryotherapy. Br J Cancer. 2009 Jun 16;100(12):1889-95.

Aquaporins were inhibited using mercuric chloride (HgCl (2)) and small interfering RNA (siRNA) duplex, and cell survival was assessed using a colorimetric assay.
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9829975 Meinild AK, Klaerke DA, Zeuthen T: Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5. J Biol Chem. 1998 Dec 4;273(49):32446-51.


The reflection coefficients (sigma) of urea, glycerol, acetamide, and formamide at 23 degreesC were: AQP0: 1, 1, 0.8, 0.6; AQP1: 1, 0.8, 1, 1; AQP2: 1, 0.8, 1, 1; AQP3: 1, 0.2, 0.7, 0.4; AQP4: 1, 0.9, 1, 1; and AQP5: 1, 1, 1, 0.8.
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10958345 Kierbel A, Capurro C, Pisam M, Gobin R, Christensen BM, Nielsen S, Parisi M: Effects of medium hypertonicity on water permeability in the mammalian rectum: ultrastructural and molecular correlates. Pflugers Arch. 2000 Aug;440(4):609-18.


Immunohistochemical studies showed the expression of aquaporin 3 (AQP3) at the basolateral membrane of epithelial cells in the rat.
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10205677 Ko SB, Uchida S, Naruse S, Kuwahara M, Ishibashi K, Marumo F, Hayakawa T, Sasaki S: Cloning and functional expression of rAOP9L a new member of aquaporin family from rat liver. Biochem Mol Biol Int. 1999 Feb;47(2):309-18.


A 1408 bp cDNA was sequenced (designated rAQP9L) with a 885 bp open reading frame encoding a 295 amino acid hydrophobic protein. rAQP9L has the greatest amino-acid sequence identity with human AQP9 (75%) and a less homology with AQP3 (49%) and AQP7 (47%).
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18344486 Philip BN, Yi SX, Elnitsky MA, Lee RE Jr: Aquaporins play a role in desiccation and freeze tolerance in larvae of the goldenrod gall fly, Eurosta solidaginis. J Exp Biol. 2008 Apr;211(Pt 7):1114-9.

Immunoblotting with mammalian anti-AQP2, -AQP3 and -AQP4 revealed corresponding aquaporin homologues in E. solidaginis, whose patterns of expression varied depending on acclimation temperature and desiccation treatment.
To examine the role of aquaporins in freeze tolerance, we froze fat body, midgut and salivary gland tissues in the presence and absence of mercuric chloride, an aquaporin inhibitor.
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