| Name | glutathione reductase |
|---|---|
| Synonyms | GLUR; GR; GRD 1; GRD1; GRase; GSR; Glutathione reductase; GRases… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2219185 | Pfaller W, Gstraunthaler G, Willinger CC: Morphology of renal tubular damage from nephrotoxins. Toxicol Lett. 1990 Sep;53(1-2):39-43. Quantitative morphological-stereological-analysis of at least two, the mercuric chloride- and the -induced experimental models of toxic acute renal failure, show a very early substantial loss of ATP-generating mitochondrial inner membrane surface as well as substantial decrease in those functions protecting cells against oxidative or auto-oxidative processes, i.e. content, activities of the free-radical-scavenging systems superoxide dismutase, peroxidase and glutathione reductase and catalase. |
31(0,1,1,1) | Details |
| 17222531 | Franco JL, Braga Hde C, Nunes AK, Ribas CM, Stringari J, Silva AP, Garcia Pomblum SC, Moro AM, Bohrer D, Santos AR, Dafre AL, Farina M: Lactational exposure to inorganic mercury: evidence of effects. Neurotoxicol Teratol. 2007 May-Jun;29(3):360-7. Epub 2006 Dec 6. This study examined the effects of inorganic mercury (mercuric chloride - HgCl2) exposure exclusively through maternal milk on biochemical parameters related to oxidative stress and thiobarbituric acid reactive substances levels, peroxidase and glutathione reductase activities) in the cerebellum of weanling mice. |
7(0,0,1,2) | Details |
| 19576259 | Rao MV, Chhunchha B: Protective role of against the mercury induced oxidative stress in the rat thyroid. Food Chem Toxicol. 2010 Jan;48(1):7-10. Epub 2009 Jul 1. Present study investigated the protective role of (MLT, 5mg/kg body wt., ip) against the long term effects of mercuric chloride (MC; 2 and 4 mg/kg body wt., po) in the thyroid gland of the rats through certain antioxidative indices like superoxide dismutase (SOD), peroxidase (GPx), glutathione reductase (GR), (GSH), catalase (CAT) and lipid peroxidation (LPO), other biochemical parameters such as succinate dehydrogenase (SDH), triphosphatase (ATPase), acid phosphatase (ACPase) and alkaline phosphatase (ALPase) were also measured. |
6(0,0,1,1) | Details |
| 11599730 | Mahboob M, Shireen KF, Atkinson A, Khan AT: Lipid peroxidation and antioxidant enzyme activity in different organs of mice exposed to low level of mercury. J Environ Sci Health B. 2001 Sep;36(5):687-97. The effects of mercuric chloride (Hg) on lipid peroxidation (LPO), glutathione reductase (GR), peroxidase (GPx), superoxide dismutase (SOD) and (GSH) levels in different organs of mice (CD-1) were evaluated. |
6(0,0,1,1) | Details |
| 18321861 | Carvalho CM, Chew EH, Hashemy SI, Lu J, Holmgren A: Inhibition of the human thioredoxin system. J Biol Chem. 2008 May 2;283(18):11913-23. Epub 2008 Mar 4. We analyzed the effects of mercuric chloride (HgCl (2)) and monomethylmercury (MeHg) on the proteins of the mammalian thioredoxin system, thioredoxin reductase (TrxR) and thioredoxin (Trx), and of the glutaredoxin system, glutathione reductase (GR) and glutaredoxin (Grx). |
6(0,0,1,1) | Details |
| 10390852 | Hussain S, Atkinson A, Thompson SJ, Khan AT: Accumulation of mercury and its effect on antioxidant enzymes in brain, liver, and kidneys of mice. J Environ Sci Health B. 1999 Jul;34(4):645-60. The effect of mercuric chloride (HgCl2) on the activities of catalase, superoxide dismutase (SOD), peroxidase (GPx), glutathione reductase (GR) and its effect on (GSH) content were evaluated in different organs (liver, kidneys, and brain) of mice after administration at 0, 0.25, 0.5 and 1.0 mg/kg/day for 14 days. |
6(0,0,1,1) | Details |
| 18329842 | Rao MV, Gangadharan B: Antioxidative potential of against mercury induced intoxication in spermatozoa in vitro. Toxicol In Vitro. 2008 Jun;22(4):935-42. Epub 2008 Feb 2. Sperm samples were dispersed in RPS medium (pH 6.9) and incubated with mercury in the form of mercuric chloride (MC) at three different concentrations (1 microM, 10 microM, 100 microM), (MLT) at a concentration (100 microM) and mercuric chloride+melatonin (100 microM each) for 3h at 32 degrees C. An aliquot of sperm sample was homogenised, centrifuged and used for the assay of superoxide dismutase, peroxidase, glutathione reductase, TBARS assay to detect lipid peroxidation and peroxide generation assay. |
2(0,0,0,2) | Details |
| 15977196 | Bando I, Reus MI, Andres D, Cascales M: Endogenous antioxidant defence system in rat liver following mercury oral intoxication. J Biochem Mol Toxicol. 2005;19(3):154-61. Other enzyme activities related to the redox cycle, such as glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G6PDH), also increased progressively. |
1(0,0,0,1) | Details |
| 19636703 | Monteiro DA, Rantin FT, Kalinin AL: Inorganic mercury exposure: toxicological effects, oxidative stress biomarkers and bioaccumulation in the tropical freshwater fish matrinxa, Brycon amazonicus (Spix and Agassiz, 1829). Ecotoxicology. 2010 Jan;19(1):105-23. Epub 2009 Jul 28. Increases in superoxide dismutase, catalase, peroxidase (GPx), glutathione S-transferase (GST) and glutathione reductase (GR) were observed in all tissues after HgCl (2) exposure, except for white muscle GR activity and hepatic GPx. |
1(0,0,0,1) | Details |
| 2554540 | Hellstrom-Lindahl E, Oskarsson A: Increased availability of mercury in rat hepatocytes by complex formation with diethyldithiocarbamate. Toxicol Lett. 1989 Oct;49(1):87-98. The availability of different chemical forms of mercury (Hg) was studied in primary cultures of rat hepatocytes incubated with mercuric (HgAc), mercuric diethyldithiocarbamate (Hg (DTC) 2) or methyl mercuric chloride (MeHgCl), labelled with 203Hg. On the other hand, glutathione reductase was inhibited to a higher degree by HgAc than by Hg (DTC) 2, indicating that Hg (DTC) 2 remains at least temporarily in the complexed form and that the enzyme is less susceptible to Hg in this form. |
1(0,0,0,1) | Details |
| 17033861 | Ghosh SK, Ghosh S, Gachhui R, Mandal A: Mercury and organomercurial resistance in Rhodotorula rubra: activation of glutathione reductase. Bull Environ Contam Toxicol. 2006 Sep;77(3):351-8. |
1(0,0,0,1) | Details |
| 7988676 | Rennex D, Pickett M, Bradley M: In vivo and in vitro effects of mutagenesis of active site residues of mercuric reductase. FEBS Lett. 1994 Dec 5;355(3):220-2. Tyr605 occupies the same position in mercuric reductase as the active site His residue in the related enzyme glutathione reductase. |
1(0,0,0,1) | Details |
| 10395986 | Kaliman PA, Barannik TV: Regulation of delta-aminolevulinate synthase activity during the development of oxidative stress. Biochemistry. 1999 Jun;64(6):699-704. Activities of rat liver synthetase (delta-ALAS), glutathione reductase (GR), and glucose-6-phosphate dehydrogenase (G6PDH), GSH content in the liver, and the absorption spectrum of blood serum were investigated after CoCl2, HgCl2, or beta-adrenoblocker injection and after CoCl2 and co-administration. |
1(0,0,0,1) | Details |
| 17207565 | Sarwar Alam M, Kaur G, Jabbar Z, Javed K, Athar M: Eruca sativa seeds possess antioxidant activity and exert a protective effect on mercuric chloride induced renal toxicity. Food Chem Toxicol. 2007 Jun;45(6):910-20. Epub 2006 Nov 29. Oxidative modulation of renal tissues following HgCl (2) exposure was evident from a significant elevation in lipid peroxidation and attenuation in (GSH) contents and activities of antioxidant enzymes viz., catalase (CAT), peroxidase (GPX), superoxide dismutase (SOD) and glutathione reductase (GR). |
1(0,0,0,1) | Details |