| Name | cytochrome c |
|---|---|
| Synonyms | CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12516873 | Simon-Giavarotti KA, Giavarotti L, Gomes LF, Lima AF, Veridiano AM, Garcia EA, Mora OA, Fernandez V, Videla LA, Junqueira VB: Enhancement of lindane-induced liver oxidative stress and hepatotoxicity by thyroid hormone is reduced by gadolinium Free Radic Res. 2002 Oct;36(10):1033-9. Hyperthyroid animals treated with lindane exhibit enhanced liver microsomal (O2.-) production and cytochrome c reductase activity, with lower levels of cytochrome P450, superoxide dismutase (SOD) and catalase activity, and (GSH) content over control values. |
31(0,1,1,1) | Details |
| 15620088 | Sheweita SA: Carcinogen-metabolizing enzymes and insecticides. J Environ Sci Health B. 2004;39(5-6):805-18. The present study was under taken to demonstrate the effect of some commonly used insecticides on the activity of cytochrome P450 system including cytochrome b5, aryl hydrocarbon [benzo (a) pyrene] hydroxylase (AHH), N-nirosodimethylamine N-demethylase I [NDMA-dI] and -cytochrome c reductase as phase I of drug oxidation. In addition, the activity of glutathione S-transferase (GST), glutathione reductase (GR), and the level of (GSH) were determined in the liver of male mice after oral administration of sumithion, dursban, chlordane, methoxychlor, heptachlor epoxide, and lindane as single (24h) or as repeated doses for six consecutive days. |
2(0,0,0,2) | Details |
| 7681024 | Bagchi M, Stohs SJ: In vitro induction of reactive species by 2,3,7,8-tetrachlorodibenzo-p-dioxin, endrin, and lindane in rat peritoneal macrophages, and hepatic mitochondria and microsomes. Free Radic Biol Med. 1993 Jan;14(1):11-8. When hepatic mitochondria were incubated with endrin and lindane for 15 min at 100 ng/ml, increases in cytochrome c reduction of 6.5- and 7.5-fold occurred, respectively, while when microsomes were incubated with these same two PCH, increases in cytochrome c reduction of 8.6- and 11.6-fold occurred, respectively. |
83(1,1,1,3) | Details |
| 19038305 | Saradha B, Vaithinathan S, Mathur PP: Lindane induces testicular apoptosis in adult Wistar rats through the involvement of Fas-FasL and mitochondria-dependent pathways. Toxicology. 2009 Jan 31;255(3):131-9. Epub 2008 Nov 5. To elucidate the mechanism (s) underpinning the gonadal effects of lindane, we sought to investigate the levels of apoptosis-related proteins, namely cytochrome c, caspase-3 and-9, Fas and FasL in the testis of adult rats. |
32(0,1,1,2) | Details |
| 15716478 | Loch-Caruso R, Upham BL, Harris C, Trosko JE: Divergent roles for in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicol Sci. 2005 May;85(1):694-702. Epub 2005 Feb 16. Exposure to 100 or 200 microM lindane rapidly (within 1 min) increased myometrial cell generation of as measured by superoxide dismutase-inhibitable cytochrome c reduction, and production remained elevated for up to 60 min of exposure. |
31(0,1,1,1) | Details |
| 7509413 | Bainy AC, Arisi AC, Azzalis LA, Simizu K, Barros SB, Videla LA, Junqueira VB: Differential effects of short-term lindane administration on parameters related to oxidative stress in rat liver and erythrocytes. J Biochem Toxicol. 1993 Dec;8(4):187-94. Lindane induced an oxidative stress condition in the liver, which is related to an enhancement in microsomal -cytochrome c reductase and oxidase activities, formation and cytochrome P450 content, produced independently of the time of treatment. |
6(0,0,1,1) | Details |
| 7512143 | Junqueira VB, Bainy AC, Arisi AC, Azzalis LA, Simizu K, Pimentel R, Barros SB, Videla LA: Acute lindane intoxication: a study on lindane tissue concentration and oxidative stress-related parameters in liver and erythrocytes. J Biochem Toxicol. 1994 Feb;9(1):9-15. The liver from lindane-treated rats showed an enhanced microsomal pro-oxidant activity, evidenced by higher cytochrome P450 content and -cytochrome c reductase and oxidase activities. |
6(0,0,1,1) | Details |
| 8584504 | Puri S, Kohli KK: Differences in hepatic drug metabolizing enzymes and their response to lindane in rat, rabbit and monkey. Pharmacol Toxicol. 1995 Aug;77(2):136-41. Untreated rabbit liver microsomes demonstrated the highest content of cytochrome P450 and activity of cytochrome c reductase compared to rat and monkey. |
1(0,0,0,1) | Details |
| 19041923 | Zucchini-Pascal N, de Sousa G, Rahmani R: Lindane and cell death: at the crossroads between apoptosis, necrosis and autophagy. Toxicology. 2009 Feb 4;256(1-2):32-41. Epub 2008 Nov 12. This disruption of cell suicide was linked to Bcl-xL up-regulation, Bax down-expression, prevention of cytochrome c release, and inhibition of caspase-9 and -3 activities. |
1(0,0,0,1) | Details |
| 7544317 | Azzalis LA, Junqueira VB, Simon K, Giavarotti L, Silva MA, Kogake M, Simizu K, Barros SB, Fraga C, Porta EA: Prooxidant and antioxidant hepatic factors in rats chronically fed an regimen and treated with an acute dose of lindane. Free Radic Biol Med. 1995 Aug;19(2):147-59. |
0(0,0,0,0) | Details |