| Name | enkephalin |
|---|---|
| Synonyms | Met enkephalin; enkephalin; M enkephalin |
| Name | dithioether |
|---|---|
| CAS | dimethyl disulfide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3037296 | Mosberg HI, Omnaas JR, Goldstein A: Structural requirements for delta opioid receptor binding. . Mol Pharmacol. 1987 Jun;31(6):599-602. Structural features influencing opioid activity of enkephalin analogs were investigated through the synthesis and evaluation of opioid receptor binding affinities of a series of cyclic dithioether-containing analogs and structurally related linear analogs of the cyclic, disulfide-containing peptides, [D-Pen2, D-Pen5] enkephalin and [D-Pen2, L-Pen5] enkephalin, where Pen (penicillamine) is beta, beta-dimethylcysteine. |
33(0,1,1,3) | Details |
| 2845204 | Mosberg HI, Omnaas JR, Medzihradsky F, Smith CB: Cyclic, disulfide- and dithioether-containing opioid tetrapeptides: development of a ligand with high delta opioid receptor selectivity and affinity. Life Sci. 1988;43(12):1013-20. These peptides are related to previously reported penicillamine-containing pentapeptide enkephalin analogs but lack the central residue of the latter and were designed to assess the effect of decreased ring size on opioid activity. |
2(0,0,0,2) | Details |
| 11082429 | McFadyen IJ, Sobczyk-Kojiro K, Schaefer MJ, Ho JC, Omnaas JR, Mosberg HI, Traynor JR: Tetrapeptide derivatives of [D-Pen (2),D-Pen (5)]-enkephalin (DPDPE) lacking an N-terminal residue are agonists at the mu-opioid receptor. J Pharmacol Exp Ther. 2000 Dec;295(3):960-6. Alteration of the bridging groups between the D-Cys (2) and D-Pen (4) residues of JH-54 from dithioether to disulfide revealed the importance of the relative position of the aromatic rings of the first and third residues in determining mu- and delta-affinities. |
1(0,0,0,1) | Details |