| 15787963 |
Przydzial MJ, Pogozheva ID, Bosse KE, Andrews SM, Tharp TA, Traynor JR, Mosberg HI: Roles of residues 3 and 4 in cyclic tetrapeptide ligand recognition by the kappa-opioid receptor. J Pept Res. 2005 Mar;65(3):333-42.
A series of cyclic, disulfide- or dithioether-containing tetrapeptides based on previously reported potent mu- and delta-selective analogs has been explored with the aim of improving their poor affinity to the kappa-opioid receptor. |
82(1,1,1,2) |
Details |
| 16218993 |
Przydzial MJ, Pogozheva ID, Ho JC, Bosse KE, Sawyer E, Traynor JR, Mosberg HI: Design of high affinity cyclic pentapeptide ligands for kappa-opioid receptors. J Pept Res. 2005 Nov;66(5):255-62.
Indeed, peptide 8, Tyr-C [D-Cys-Phe-Phe-Cys]-NH2-cyclized via a methylene dithioether, shows picomolar binding affinity for MOR ( = 16 pm) with more than 100-fold selectivity for MOR vs. |
2(0,0,0,2) |
Details |