Protein Information

Name orexin
Synonyms HCRT; PPOX; Hcrt; Hypocretin; Hypocretin neuropeptide; OX; Orexin; Orexin precursor…

Compound Information

Name methyl bromide
CAS bromomethane

Reference List

PubMed Abstract RScore(About this table)
12531738 de Oliveira CV, Rosas-Arellano MP, Solano-Flores LP, Ciriello J: Cardiovascular effects of hypocretin-1 in nucleus of the solitary tract. Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):H1369-77. Epub 2002 Dec 12.

Intravenous administration of the muscarinic receptor blocker atropine methyl bromide abolished the bradycardia response and attenuated the depressor response, whereas subsequent administration of the nicotinic receptor blocker hexamethonium bromide abolished the remaining MAP response.
8(0,0,0,8) Details
12573979 Ciriello J, de Oliveira CV: Cardiac effects of hypocretin-1 in nucleus ambiguus. Am J Physiol Regul Integr Comp Physiol. 2003 Jun;284(6):R1611-20. Epub 2003 Feb 6.

Administration (iv) of the muscarinic receptor antagonist atropine methyl bromide or ipsilateral vagotomy abolished the HR response, indicating that the HR response was due to activation of vagal cardiomotor neurons.
1(0,0,0,1) Details
14575880 Ciriello J, Li Z, de Oliveira CV: Cardioacceleratory responses to hypocretin-1 injections into rostral ventromedial medulla. Brain Res. 2003 Nov 21;991(1-2):84-95.

Administration (i.v.) of the muscarinic receptor antagonist atropine methyl bromide significantly attenuated ( approximately 62%) the HR response whereas, the total autonomic blockade abolished the HR response.
3(0,0,0,3) Details