| Name | beta 3 adrenergic receptor |
|---|---|
| Synonyms | ADRB 3; ADRB3; ADRB3R; B3AR; BETA3AR; Beta 3 adrenergic receptor; Beta 3 adrenoceptor; Beta 3 adrenoreceptor… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19608416 | Hattori K, Orita M, Toda S, Imanishi M, Itou S, Nakajima Y, Tanabe D, Washizuka K, Araki T, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F: Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the beta2-adrenergic receptor: part 6. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4679-83. Epub 2009 Jun 25. As an extension of research, we have investigated modification of left-hand side (LHS) of biphenyl analogues containing an acylsulfonamide moiety in the development of potent and selective human beta (3)-adrenergic receptor (AR) agonists. |
31(0,1,1,1) | Details |
| 18752946 | Nakajima Y, Imanishi M, Itou S, Hamashima H, Tomishima Y, Washizuka K, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Hattori K: Discovery of novel series of derivatives containing biphenyl ether moiety as potent and selective human beta (3)-adrenergic receptor agonists: Part IV. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5037-40. Epub 2008 Aug 7. |
31(0,1,1,1) | Details |
| 18307290 | Imanishi M, Tomishima Y, Itou S, Hamashima H, Nakajima Y, Washizuka K, Sakurai M, Matsui S, Imamura E, Ueshima K, Yamamoto T, Yamamoto N, Ishikawa H, Nakano K, Unami N, Hamada K, Matsumura Y, Takamura F, Hattori K: Discovery of a novel series of biphenyl derivatives as potent and selective human beta3-adrenergic receptor agonists with good oral bioavailability. J Med Chem. 2008 Mar 27;51(6):1925-44. Epub 2008 Feb 29. A novel class of biphenyl analogues containing a moiety based on lead compound 8i have been identified as potent and selective human beta 3 adrenergic receptor (beta 3-AR) agonists with good oral bioavailability and long plasma half-life. |
31(0,1,1,1) | Details |
| 19133996 | Vrydag W, Alewijnse AE, Michel MC: Do gene polymorphisms alone or in combination affect the function of human beta3-adrenoceptors?. Br J Pharmacol. 2009 Jan;156(1):127-34. BACKGROUND AND PURPOSE: beta (3)-Adrenoceptors mediate many important physiological functions, for example, in the urinary bladder. |
3(0,0,0,3) | Details |
| 18372395 | Grudell AB, Camilleri M, Jensen KL, Foxx-Orenstein AE, Burton DD, Ryks MD, Baxter KL, Cox DS, Dukes GE, Kelleher DL, Zinsmeister AR: Dose-response effect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal bowel function, and somatostatin levels in health. Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1114-9. Epub 2008 Mar 27. beta (3)-Adrenoceptors (beta (3)-AR) are expressed by cholinergic myenteric neurons and beta (3)-AR agonists are effective in experimental models of diarrhea. |
1(0,0,0,1) | Details |