| Name | mitogen activated protein kinase (protein family or complex) |
|---|---|
| Synonyms | MAPK; mitogen activated protein kinase; mitogen activated protein kinases |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19219913 | Wen J, Fu AF, Chen LJ, Xie XJ, Yang GL, Chen XC, Wang YS, Li J, Chen P, Tang MH, Shao XM, Lu Y, Zhao X, Wei YQ: Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in xenograft tumor model. Int J Cancer. 2009 Jun 1;124(11):2709-18. Western blotting analysis showed that liposomal honokiol-inhibited Akt and MAPK phosphorylation in 2 endothelial cells, and downregulated expressions of VEGFR-2 of human vascular endothelial cells and VEGFR-3 of lymphatic endothelial cells. |
1(0,0,0,1) | Details |
| 18971559 | Kanome T, Watanabe T, Nishio K, Takahashi K, Hongo S, Miyazaki A: Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages. Hypertens Res. 2008 Sep;31(9):1801-10. Treatment with a G-protein inactivator (GDP-beta-S), a c-Src tyrosine kinase inhibitor (PP2), a protein kinase C (PKC) inhibitor (rottlerin), or a mitogen activated protein kinase (MAPK) kinase inhibitor (PD98059) significantly reduced Ang II-induced ACAT1 protein expression. |
1(0,0,0,1) | Details |
| 19772287 | Aston NM, Bamborough P, Buckton JB, Edwards CD, Holmes DS, Jones KL, Patel VK, Smee PA, Somers DO, Vitulli G, Walker AL: p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression. J Med Chem. 2009 Oct 22;52(20):6257-69. |
1(0,0,0,1) | Details |
| 18378223 | Zhou HY, Shin EM, Guo LY, Youn UJ, Bae K, Kang SS, Zou LB, Kim YS: Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB, JNK and p38 MAPK inactivation. Eur J Pharmacol. 2008 May 31;586(1-3):340-9. Epub 2008 Feb 26. |
1(0,0,0,1) | Details |
| 18507762 | Deng J, Qian Y, Geng L, Chen J, Wang X, Xie H, Yan S, Jiang G, Zhou L, Zheng S: Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (hepG2). Liver Int. 2008 Dec;28(10):1458-64. Epub 2008 May 26. In addition, honokiol activated the p38 mitogen-activated protein kinase (MAPK) pathway, and the inhibition of this pathway by SB203580 reduced honokiol-induced apoptosis and activation of caspase-3. |
1(0,0,0,1) | Details |
| 18956176 | Yu YN, Chen H, Li Y: Protect effect of bicyclol on cisplatin-induced nephrotoxicity in mice. Arch Toxicol. 2009 Apr;83(4):381-7. Epub 2008 Oct 28. Bicyclol suppressed cisplatin-induced extracelluar signal regulated kinases 1/2 and p38 mitogen-activated protein kinase activation in the kidney of mice. |
1(0,0,0,1) | Details |
| 19244105 | VanBrocklin MW, Verhaegen M, Soengas MS, Holmen SL: Mitogen-activated protein kinase inhibition induces translocation of Bmf to promote apoptosis in melanoma. Cancer Res. 2009 Mar 1;69(5):1985-94. Epub 2009 Feb 24. |
3(0,0,0,3) | Details |
| 18413146 | Idris A, Mrak E, Greig I, Guidobono F, Ralston SH, van 't Hof R: ABD56 causes osteoclast apoptosis by inhibiting the NFkappaB and ERK pathways. Biochem Biophys Res Commun. 2008 Jun 20;371(1):94-8. Epub 2008 Apr 14. As the NFkappaB and MAPK pathways are essential for osteoclast formation and survival, we studied the effects of ABD56 on these pathways. |
2(0,0,0,2) | Details |
| 18538762 | Lu C, Su LY, Lee RM, Gao YJ: mediates angiotensin II-induced potentiation of contractile response to sympathetic stimulation. Eur J Pharmacol. 2008 Jul 28;589(1-3):188-93. Epub 2008 May 5. These results showed that mediated angiotensin II-induced potentiation of contractile response to EFS and kinase-MAPK/ERK activation was involved. This potentiation was blunted by an angiotensin AT (1) receptor antagonist (2-ethoxy-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl] methyl]-1H-benzimidazole- 7-carboxylic acid, CV-11974), NAD (P) H oxidase inhibitor (apocynin), superoxide dismutase (SOD) and its mimetic tiron, but not affected by angiotensin AT (2) receptor antagonist and inhibitors of xanthine oxidase, cytochrome P450, and cyclooxygenase. |
1(0,0,0,1) | Details |
| 18959758 | Yamamoto A, Nunoshiba T, Umezu K, Enomoto T, Yamamoto K: Phenyl an Ames test-negative carcinogen, induces Hog1-dependent stress response signaling. FEBS J. 2008 Nov;275(22):5733-44. Furthermore, Hog1 (a p38 MAPK homolog) was robustly phosphorylated by phenyl which can stabilize Swe1. |
1(0,0,0,1) | Details |
| 18416822 | Richardson D, Pearson RG, Kurian N, Latif ML, Garle MJ, Barrett DA, Kendall DA, Scammell BE, Reeve AJ, Chapman V: Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther. 2008;10(2):R43. Epub 2008 Apr 16. Functional activity of these receptors was determined with mitogen-activated protein kinase assays. FAAH was active in the synovia of OA and RA patients and was sensitive to inhibition by URB597 (3'-(aminocarbonyl) [1,1'-biphenyl]-3-yl)-cyclohexylcarbamate). |
1(0,0,0,1) | Details |
| 18207396 | Peifer C, Urich R, Schattel V, Abadleh M, Rottig M, Kohlbacher O, Laufer S: Implications for selectivity of 3,4-diarylquinolinones as p38alphaMAP kinase inhibitors. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1431-5. Epub 2008 Jan 5. In this study we report on the specificity profiling of the MAP kinase inhibitors 1, 2, and 3 in a panel of 78 protein kinases including the MAPK isoforms p38 (alpha,beta,gamma,delta), JNK1/2/3, and ERK1/2/8 showing 3-(4-fluorophenyl)-4-pyridin-4-ylquinolin-2 (1H)-one (1) to be highly selective for p38alphaMAPK with an IC (50) of 1.8 microM. |
3(0,0,0,3) | Details |
| 18160487 | Ramnath RD, Sun J, Adhikari S, Zhi L, Bhatia M: Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. Am J Physiol Cell Physiol. 2008 Mar;294(3):C683-92. Epub 2007 Dec 26. In this study, we showed that SP stimulated an early phosphorylation of PKC isoform PKC-delta followed by increased activation of MAPKKK MEKK1 and MAPK ERK and JNK as well as transcription factor NF-kappaB and activator protein-1 driven chemokine production. |
1(0,0,0,1) | Details |
| 18949061 | Hendrickson AW, Meng XW, Kaufmann SH: Anticancer therapy: boosting the bang of Bim. J Clin Invest. 2008 Nov;118(11):3582-4. Epub 2008 Oct 23. Even though activating mutations of B-Raf, a kinase atop the MAPK signaling cascade, reportedly sensitize tumor cells to inhibitors, Raf and inhibitors have exhibited limited clinical activity. |
1(0,0,0,1) | Details |
| 19107823 | Lee KH, Kim AJ, Choi EM: Antioxidant and antiinflammatory activity of pine pollen extract in vitro. Phytother Res. 2009 Jan;23(1):41-8. Thereafter, the study investigated the effects of PPE in modulating the production of pro-inflammatory mediators in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages, and the effect of PPE on interleukin (IL)-1beta-induced matrix metalloproteinases (MMPs) production and mitogen-activated protein kinases (MAPKs) activation in the human synovial sarcoma cell line, SW982. |
1(0,0,0,1) | Details |
| 18367166 | Chang HL, Chang FR, Chen JS, Wang HP, Wu YH, Wang CC, Wu YC, Hwang TL: Inhibitory effects of 16-hydroxycleroda-3,13 (14) E-dien-15-oic acid on and elastase release in human neutrophils through multiple mechanisms. Eur J Pharmacol. 2008 May 31;586(1-3):332-9. Epub 2008 Mar 4. Furthermore, PL3S attenuated the FMLP-induced protein kinase B (AKT) and p38 mitogen-activated protein kinase phosphorylation. |
1(0,0,0,1) | Details |
| 19655415 | Yao K, Zhang L, Ye PP, Tang XJ, Zhang YD: Protective effect of magnolol against peroxide-induced oxidative stress in human lens epithelial cells. Am J Chin Med. 2009;37(4):785-96. Moreover, magnolol attenuated the deactivation of ERK/MAPK (extracellular signal-regulated kinase/mitogen activated protein kinase) and the enhanced activation of p38, JNK (c-Jun N-terminal kinase) induced by H2O2. |
1(0,0,0,1) | Details |