| Name | G protein |
|---|---|
| Synonyms | G gamma I; Guanine nucleotide binding protein 2; G protein; GNG 2; GNG2; GNGT 2; GNGT2; Guanine nucleotide binding protein gamma 2… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19625579 | Bennett KA, Langmead CJ, Wise A, Milligan G: Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha (o1) by the Ghrelin receptor. Mol Pharmacol. 2009 Oct;76(4):802-11. Epub 2009 Jul 22. In membranes prepared from cells coexpressing the human ghrelin receptor and the G protein Galpha (o1), N-[1 (R)-1, 2-dihydro-1-ethanesulfonylspiro-3H--3,4'-piperidin)-1'-yl] carbonyl-2 -(phenylmethoxy)-ethyl-2-amino-2-methylpropanamide (MK-677), growth hormone-releasing peptide 6 (GHRP-6), and the 2 (R)-hydroxypropyl derivative of 3-amino-3-methyl-N-(2,3,4,5-tetrahydro-2-oxo-1-([2'-(1H-tetrazol-5-yl) (1,1'-biphenyl)-4-yl] methyl)-1H-1-benzazepin-3 (R)-yl)-butanamide (L-692,585) each functioned as direct agonists, and each displayed higher efficacy than ghrelin. |
31(0,1,1,1) | Details |
| 18971559 | Kanome T, Watanabe T, Nishio K, Takahashi K, Hongo S, Miyazaki A: Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages. Hypertens Res. 2008 Sep;31(9):1801-10. Treatment with a G-protein inactivator (GDP-beta-S), a c-Src tyrosine kinase inhibitor (PP2), a protein kinase C (PKC) inhibitor (rottlerin), or a mitogen activated protein kinase (MAPK) kinase inhibitor (PD98059) significantly reduced Ang II-induced ACAT1 protein expression. |
2(0,0,0,2) | Details |
| 17944864 | Vinod KY, Sanguino E, Yalamanchili R, Manzanares J, Hungund BL: Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to J Neurochem. 2008 Jan;104(1):233-43. Epub 2007 Oct 17. The deletion of FAAH gene or the inhibition of FAAH by carbamoyl-biphenyl-3-yl-cyclohexylcarbamate (URB597) (0.1 mg/kg) markedly increased the preference for The CB (1) receptor and proenkephalin gene expressions, and CB (1) receptor and mu-opioid (MO) receptor-mediated G-protein activation were found to be significantly lower in the caudate-putamen, nucleus accumbens core and shell of FAAH -/- than +/+ mice. |
2(0,0,0,2) | Details |