Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name malathion
CAS diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate

Reference List

PubMed Abstract RScore(About this table)
17974266 Zhang YL, Mu W, Chen ZL, Han ZR, Ma C, Zhai RH: [Susceptibility and related physiological and biochemical mechanisms of Carposina niponensis Walsingham larvae on six insecticides before and after overwintering]. J Environ Biol. 2008 Mar;29(2):259-62.

The study with impregnating method showed that after overwintering, the susceptibility of Carposina niponensis larvae on triazophos, phoxim, chlorpyrifos, malathion, lambda-cyhalothrin and abamectin was 34.50, 16.71, 3.89, 3.28, 5.90 and 2.73 times as much as that before overwintering, the total protein, glycogen and fat contents and carboxylesterase, acid phosphatase, alkaline phosphatase, glutathione-S-transferase, superoxide dismutase, catalase and peroxidase activities in C. niponensis larvae were decreased by 17.10%, 41.76% and 30.08%, 62.36%, 53.47%, 76.19%, 80.60%, 18.77%, 14.16% and 64.02%, respectively, and the activity of acetylcholinesterase, the target enzyme of many insecticides, was 1.41 times as much as that before overwintering.
31(0,1,1,1) Details
7112611 Saigal S, Bhatnagar VK, Malviya AN: Effect of selected pesticides on alkaline and acid phosphatase in the rat. Toxicol Lett. 1980 Oct;6(6):411-5.

Renal and hepatic alkaline phosphatase activity was significantly inhibited in all cases, while treatment with malathion and phosalone resulted in an increase in intestinal alkaline phosphatase activity.
37(0,1,2,2) Details
6490128 Vaishwanar I, Mallik S: The effect of malathion dust on certain tissues of male rats fed varying levels of dietary protein. Indian J Physiol Pharmacol. 1984 Jan-Mar;28(1):35-41.

Animals kept on low protein diets (5% and 10%) when exposed to malathion dust showed significant increase in the activities of GOT and alkaline phosphatase in liver, kidney, brain, lungs and spleen, while a marked inhibition in the activity of Ache was observed under similar treatment.
31(0,1,1,1) Details
2434299 Kumar K, Ansari BA: Malathion toxicity: effect on the liver of the fish Brachydanio rerio (Cyprinidae). Ecotoxicol Environ Saf. 1986 Dec;12(3):199-205.

There was marked inhibition in DNA, RNA, and protein contents and the activities of acid and alkaline phosphatase.
1(0,0,0,1) Details
1781938 Neskovic NK, Karan VZ, Vitorovic SL, Vojinovic VD: Toxic effects of bound malathion residues in rats. Ying Yong Sheng Tai Xue Bao. 2007 Aug;18(8):1913-6.

In both, males and females, there was an increase in SGPT activity (lower dose), and in alkaline phosphatase in females (higher dose).
1(0,0,0,1) Details
19941925 Kalender S, Uzun FG, Durak D, Demir F, Kalender Y: Malathion-induced hepatotoxicity in rats: the effects of vitamins C and E. Food Chem Toxicol. 2010 Feb;48(2):633-8. Epub 2009 Nov 23.

Compared to the control group, the two groups also had significantly higher serum total cholesterol, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) levels, and significantly lower triglyceride and very low density lipoprotein (VLDL) levels.
1(0,0,0,1) Details
1527357 Zayed SM, Farghaly M, Mostafa IY: Bioavailability to rats and toxicological potential in mice of bound residues of malathion in beans. J Environ Sci Health B. 1992 Aug;27(4):341-6.

Increased levels of serum glutamic oxaloacetic transaminase and alkaline phosphatase were also observed.
1(0,0,0,1) Details
2126817 Jabbar A, Khawaja SA, Iqbal A, Malik SA: Effect of malathion and methyl-parathion on rat liver enzymes. J Pak Med Assoc. 1990 Apr;40(4):85-9.

Short term (24 hr) and long term (4 weeks) treatment with insecticides resulted in increased specific activities of liver enzymes, Acid phosphatase, Alkaline phosphatase, Glutamate dehydrogenase, Glutamate oxaloacetate transaminase and Glutamate pyruvate transaminase.
1(0,0,0,1) Details
18831386 Choudhary N, Goyal R, Joshi SC: Effect of malathion on reproductive system of male rats. 246.

The activity of testicular enzyme acid phosphatase increased significantly while decreased alkaline phosphatase activity was found.
1(0,0,0,1) Details
12600110 Yang Y, Zhou M, Zhang H, Mao Y, Guo M: [Effects of isocarbophos on the integrity of epidermic cell membrane of human skin]. Hua Xi Yi Ke Da Xue Xue Bao. 2001 Jun;32(2):286-7


We tested the activities of LDH and alkaline phosphatase (ALP) in the medium in different isocarbophos dosage conditions.
1(0,0,0,1) Details
2126808 Jabbar A, Khawaja SA, Iqbal A, Malik SA: Effect of malathion and methyl-parathion on rat liver enzymes. J Pak Med Assoc. 1990 Nov;40(11):266-70.

Short term (24 hr.) and long term (4 weeks) treatment with insecticides resulted in increased specific activities of liver enzymes, Acid phosphatase, Alkaline phosphatase, Glutamate dehydrogenase, Glutamate oxaloacetate transaminase and Glutamate pyruvate transaminase.
1(0,0,0,1) Details
7444981 Chowdhury JS, Dudeja PK, Mehta SK, Mahmood A: Effect of a single oral dose of malathion on D-glucose and glycine uptake and on brush border enzymes in rat intestine. Biomed Environ Sci. 1991 Dec;4(4):423-32.

0(0,0,0,0) Details