| Name | PI3K |
|---|---|
| Synonyms | GRB 1; PI3K; GRB1; PI3 kinase p85 subunit alpha; Phosphatidyl inositol 3 kinase associated p85 alpha; Phosphatidylinositol 3 kinase regulatory subunit alpha; PtdIns 3 kinase p85 alpha… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19483651 | Crane C, Panner A, Pieper RO, Arbiser J, Parsa AT: Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function. J Immunother. 2009 Jul-Aug;32(6):585-92. |
5(0,0,0,5) | Details |
| 18158873 | Kim BH, Cho JY: Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol Sin. 2008 Jan;29(1):113-22. |
2(0,0,0,2) | Details |
| 18588872 | Liu H, Zang C, Emde A, Planas-Silva MD, Rosche M, Kuhnl A, Schulz CO, Elstner E, Possinger K, Eucker J: Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer. Eur J Pharmacol. 2008 Sep 4;591(1-3):43-51. Epub 2008 Jun 12. Finally, we showed that honokiol was able to attenuate the PI3K/Akt/mTOR (Phosphoinositide 3-kinases/Akt/mammalian target of rapamycin) signalling by down-regulation of Akt phosphorylation and upregulation of PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten) expression. |
1(0,0,0,1) | Details |
| 19182370 | Zhang R, Kang KA, Piao MJ, Ko DO, Wang ZH, Chang WY, You HJ, Lee IK, Kim BJ, Kang SS, Hyun JW: Preventive effect of 7,8-dihydroxyflavone against oxidative stress induced genotoxicity. Biol Pharm Bull. 2009 Feb;32(2):166-71. In addition, LY294002, which is phosphatidylinositol 3 kinase (PI3K, upstream of Akt) inhibitor, attenuated the protective effect of 7,8-dihydroxyflavone against H (2) O (2)-induced cell damage. |
1(0,0,0,1) | Details |
| 18254244 | Li HB, Yi X, Gao JM, Ying XX, Guan HQ, Li JC: Magnolol-induced H460 cells death via autophagy but not apoptosis. Arch Pharm Res. 2007 Dec;30(12):1566-74. Blockade of PI3K/PTEN/Akt pathway is maybe related to Magnolol-induced autophagy. |
1(0,0,0,1) | Details |
| 19229860 | Lee DH, Szczepanski MJ, Lee YJ: Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells. J Cell Biochem. 2009 Apr 15;106(6):1113-22. |
1(0,0,0,1) | Details |