| Name | p38alpha |
|---|---|
| Synonyms | CSAID binding protein 1; Protein serine/threonine kinase; p38; CSAID binding protein 2; CSAID binding protein; CSBP; CSBP 1; CSBP 2… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17981461 | Angell RM, Angell TD, Bamborough P, Brown D, Brown M, Buckton JB, Cockerill SG, Edwards CD, Jones KL, Longstaff T, Smee PA, Smith KJ, Somers DO, Walker AL, Willson M: Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR. Bioorg Med Chem Lett. 2008 Jan 1;18(1):324-8. Epub 2007 Oct 17. The biphenyl amides are a novel series of p38 MAP kinase inhibitors. |
32(0,1,1,2) | Details |
| 18602262 | Angell RM, Angell TD, Bamborough P, Bamford MJ, Chung CW, Cockerill SG, Flack SS, Jones KL, Laine DI, Longstaff T, Ludbrook S, Pearson R, Smith KJ, Smee PA, Somers DO, Walker AL: Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4433-7. Epub 2008 Jun 12. The biphenyl amides (BPAs) are a series of p38alpha MAP kinase inhibitors. |
32(0,1,1,2) | Details |
| 18006306 | Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL: Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode. Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. |
31(0,1,1,1) | Details |
| 19772287 | Aston NM, Bamborough P, Buckton JB, Edwards CD, Holmes DS, Jones KL, Patel VK, Smee PA, Somers DO, Vitulli G, Walker AL: p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression. J Med Chem. 2009 Oct 22;52(20):6257-69. |
3(0,0,0,3) | Details |
| 18614366 | Angell R, Aston NM, Bamborough P, Buckton JB, Cockerill S, deBoeck SJ, Edwards CD, Holmes DS, Jones KL, Laine DI, Patel S, Smee PA, Smith KJ, Somers DO, Walker AL: Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4428-32. Epub 2008 Jun 18. The biphenyl amides (BPAs) are a novel series of p38alpha MAP kinase inhibitor. |
31(0,1,1,1) | Details |
| 18207396 | Peifer C, Urich R, Schattel V, Abadleh M, Rottig M, Kohlbacher O, Laufer S: Implications for selectivity of 3,4-diarylquinolinones as p38alphaMAP kinase inhibitors. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1431-5. Epub 2008 Jan 5. In contrast, besides p38alpha the isoxazoles 2 and 3 significantly inhibited JNK2/3 and further kinases beyond the MAPK family such as PKA, PKD, Lck, and CK1. |
2(0,0,0,2) | Details |